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Dr. Francisco José Blanco Gutiérrez

Dr. Francisco José Blanco Gutiérrez

Ikerbasque Research Professor
(Spain)

  • Doctor in Chemistry 1992 from the University Complutense of Madrid.
  • 15 years research experience in centres in Germany, the United States and Spain.
  • Research line: Biosciences, protein structures.
  • Comes from the National Centre for Oncological Research (CNIO) in Madrid.
  • Has joined the CIC bioGUNE in the Technological Park in Bizkaia.

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Publications

2011

I GMuñoz, J Prieto, S Subramanian, J Coloma, P Redondo, M Villate, N Merino, M Marenchino, M D\'Abramo, F L Gervasio, S Grizot, F Daboussi, J Smith, I Chion-Sotinel, F Pâques, P Duchateau, A Alibés, F Stricher, L Serrano, FJ Blanco, G Montoya (2011)
Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus
Nucleic Acids Res

M Abad, A Moreno, A Palacios, M Narita, FJ Blanco, G Moreno-Bueno, M Narita, I Palmero (2011)
The tumor suppressor ING1 contributes to epigenetic control of cellular senescence
Aging Cell

Manikwar P, Tejo BA, Shinogle H, Moore DS, Zimmerman T, Blanco F, Siahaan TJ (2011)
Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes
Theranostics

Alfredo De Biasio, Ricardo Sánchez, Jesús Prieto, Maider Villate, Ramón Campos-Olivas, Francisco J. Blanco (2011)
Reduced stability and increased dynamics in the human proliferating cell nuclear antigen (PCNA) relative to the yeast homolog
PlosOne

2010

Marcaida MJ, Muñoz IG, Blanco FJ, Prieto J, Montoya G (2010)
Homing endonucleases: from basics to therapeutic applications
Cellular and Molecular Life Sciences

A. López de Opakua, T. Diercks, AR Viguera & FJ Blanco (2010)
NMR assignment and backbone dynamics of the pore-forming domain of colicin A
Biomolecular NMR asignments

Palacios A, Moreno A, Oliveira BL, Rivera T, Prieto J, García P, Fernández-Fernández MR, Bernadó P, Palmero I, Blanco FJ (2010)
The Dimeric Structure and the Bivalent Recognition of H3K4me3 by the Tumor Suppressor ING4 Suggests a Mechanism for Enhanced Targeting of the HBO1 Complex to Chromatin.
Journal of Molecular Biology

Blanco FJ, Villegas S, Benitez S, Bancells C, Diercks T, Ordonez-Llanos J, Sanchez-Quesada JL. (2010)
2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles
Journal of lipid research

S. Culurgioni, I. Muñoz, A. Palacios, P. Redondo, FJ Blanco and G. Montoya (2010)
Crystallization and preliminary X-ray diffraction analysis on the dimerization domain of the tumour suppressor ING4
Acta crystallographica. Section F, Structural biology and crystallization communications

Sánchez R, Pantoja-Uceda D, Prieto J, Diercks T, Marcaida MJ, Montoya G, Campos-Olivas R, Blanco FJ (2010)
Solution Structure of Human Growth Arrest and DNA Damage 45alfa (Gadd45alfa) and its Interactions with Proliferating Cell Nuclear Antigen (PCNA) and Aurora A Kinase
Journal of Biological Chemistry

C Bancells, S Villegas, FJ Blanco, S Benítez, I Gállego, L Beloki, M Pérez-Cuellar, J Ordóñez-Llanos, JL Sánchez-Quesada (2010)
Aggregated electronegative low-density lipoprotein in human plasma shows high tendency to phospholipolysis and particle fusion
Journal of Biological Chemistry

Moreno A, Palacios, Orgaz JL, Jiménez B, Blanco FJ, Palmero I (2010)
Functional impact of cancer-associated mutations in the tumor suppressor protein ING4
Carcinogenesis

Blanco FJ, Valle M, Millet O (2010)
The Structural Challenge
Public Review Service, European Union

2009

AM Cuesta, D Sánchez-Martín, L Sanz, J Bonet, M Compte, L Kremer, FJ Blanco, B Oliva, and L Álvarez-Vallina (2009)
In Vivo Tumor Targeting and Imaging with Engineered Trivalent Antibody Fragments Containing Collagen-Derived Sequences
PLoS One

S Grizot, J Smith, F Daboussi, J Prieto, P Redondo, N Merino, M Villate, S Thomas, L Lemaire, G Montoya, FJ Blanco, F Pâques, P Duchateau (2009)
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
Nucleic Acids Research

2008

Palacios A, Muñoz IG, Pantoja-Uceda D, Marcaida MJ, Torres D, Martín-García JM, Luque I, Montoya G, Blanco FJ. (2008)
Molecular basis of histone H3K4ME3 recognition by ING4
Journal of Biological Chemistry

Muñoz IG, Blanco FJ. And Montoya G (2008)
On the relevance of defining protein structures in cancer research
Cliical and Translational Oncology

Pantoja-Uceda D, Arolas JL, García P, López-Hernández E, Padró D, Aviles FX, Blanco FJ. (2008)
The NMR Structure and Dynamics of the Two-Domain Tick Carboxypeptidase Inhibitor Reveal Flexibility in Its Free Form and Stiffness upon Binding to Human Carboxypeptidase B
Biochemistry

Arolas JL, Pantoja-Uceda D, Ventura, S, Blanco FJ. & Aviles FX, (2008)
The NMR structures of the major intermediates of the two-domain tick carboxypeptidase inhibitor reveal symmetry in its folding and unfolding pathways
Journal of Biological Chemistry

. L. M. Contreras, J. Gómez, J. Prieto, J.M. Clemente-Jiménez, F. J. Las Heras-Vázquez, F. Rodríguez-Vico, (2008)
The The family 52 b-xylosidase from Geobacillus stearothermophilus is a dimer: structural and biophysical characterization of a glycoside hydrolase
Biochemistry

T. Zimmerman & F. J. Blanco (2008)
Inhibitors targeting the LFA-1/ICAM-1 cell-adhesion interaction: design and mechanism of action.
Current Pharmaceutical Design

Sánchez, R., Pantoja-Uceda, D., Torres, D., Prieto, J., Campos-Olivas, R and Blanco, (2008)
NMR assignment and secondary structure of human growth arrest and DNA damage α protein (Gadd45α).
Biomolecular NMR assignments

P Redondo, J Prieto, I G. Muñoz, A Alibés, F Stricher, L Serrano, J-P Cabaniols, F Daboussi, S Arnould5, C Perez, P Duchateau, F Pâques5, F J. Blanco & G Montoya (2008)
Molecular basis of xeroderma pigmentoxum group C DNA recognition by engineered meganucleases
Nature

MJ Marcaida, J Prieto, P Redondo, AD NAdra, A Alibés, L Serrano, S Grizot, P Duchateau, F Pâques, FJ Blanco & G Montoya (2008)
The crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering
PNAS

In press

FJ Blanco, G Montoya (2011)
Transient protein-DNA/RNA interactions
FEBS J

Manikwar P, Zimmerman T, Blanco FJ, Williams TD, Siahaan TJ. (2011)
Rapid Identification of Fluorochrome Modification Sites in Proteins by LC ESI-Q-TOF Mass Spectrometry
Bioconjugate Chemistry

Doctoral dissertations

  • Structural and functional characterization of the N-terminal dimerization domain of ING4
    2006 - 2010
    Autónoma de Madrid
    Simone Curlurgioni
  • Relación estructura-función del supresor tumoral ING4
    2005 - 2009
    Universidad Complutnese de Madrid
    Alicia Palacios Ortega
  • Análisis estructural de las proteínas PCNA y GADD45a y de sus interacciones con otras proteínas implicadas
    2006 - 2009
    Universidad Autónoma de Madrid
    Ricardo Sánchez Pérez

Courses given

  • 2010
    Professor of the Máster Universitario en Biotecnología, Universidad Internacional de Andalucía, La Rábida.
  • 2010
    Professor of the Máster en Bioquímica y Biología Molecular, Universidad del País Vasco-Universidad de Cantabria, Santander
  • 2009
    Professor at the Advanced NMR course, summer school of Jaca, 17th – 22nd june 2009. Organized by the Royal Chemistry Society of Spain.

Managerial activities

  • Co-organizer of the V Reunión Bienal del Grupo Especializado de RMN de la Real Sociedad Española de Química.

Congresses, Proceedings & Scientific meetings

  • Biología molecular estructural y Resonancia Magnética Nuclear. FJ Blanco
    IX Jornadas de Química Farmacéutica (2010) Congress
    Facultad de Farmacia, EHU, Vitoria (Invited talk)
  • The Dimeric Structure and the Bivalent Recognition of H3K4me3 by the Tumor Suppressor ING4 Suggests a Mechanism for Enhanced Targeting of the HBO1 Complex to Chromatin. FJ Blanco
    Understanding Transient Molecular Interactions in Biology (2010) Congress
    cicCartuja, Sevilla, Spain (Talk)
  • NMR Studies on the Structure of HIV-Rev Protein Free and Bound to its Target RNA. F.J. Blanco
    III Worshop on Structural Biology (2009) Congress
    CIC bioGUNE, Derio (Invited talk)
  • Solid, Liquid and Semi-liquid State NMR Studies on the Structure of HIV-Rev Protein Free and Bound to its Target RNA. FJ Blanco
    IV Reunión Bienal GERM (2008) Congress
    GERMN, Sevilla, Spain (Invited talk)
 
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