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Koen Vandenbroeck

Koen Vandenbroeck

Ikerbasque Research Professor
(Belgian)

  • Doctor in Molecular Biology 1993 from the Katholieke Universiteit Leuven, Belgium.
  • 10 years of research experience in centres in Belgium (Rega Institute for Medical Research), Italy (San Raffaele Scientific Institute - DIBIT) and Ireland (Queen's University of Belfast).
  • 1999 Teva and Marion Hoechst Roussel Young Investigator Award for Multiple Sclerosis Research; 2002 ISICR Milstein Young Investigator Award
  • Research line: Neurogenomiks (Pharmacogenomics and genetics of autoimmune diseases) and ERTEK (Exploiting ER-associated cytokine folding/secretory pathways as novel therapeutic targets)
  • Comes from the post of Chair of Applied Genomics at Queen’s University Belfast, United Kingdom.

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Publications

2016

Mahurkar S., Moldovan M., Suppiah V., Sorosina M., Clarelli F., Liberatore G., Malhotra S., Montalban X., Antigüedad A., Krupa M., Jokubaitis V.G., McKay F.C., Gatt P.N., Fabis-Pedrini M.J., Martinelli V., Comi G., Lechner-Scott J., Kermode A.G., Slee (2016)
Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study.
Pharmacogenomics J.

Lopez de Lapuente A., Feliú A., Ugidos N., Mecha M., Mena J., Astobiza I., Riera J., Carillo-Salinas F., Comabella M., Montalban X., Alloza I., Guaza C. and Vandenbroeck K. (2016)
Novel insights into the multiple sclerosis risk gene ANKRD55.
J. Immunol.

Sadovnick A.D., Traboulsee A.L., Bernales C.Q., Ross J.P., Forwell A.L., Yee I.M., Guillot-Noel L., Fontaine B., Cournu-Rebeix I., Alcina A., Fedetz M., Izquierdo G., Matesanz F., Hilven K., Dubois B., Goris A., Arroyo R., Garagorri A.M., García-Martínez (2016)
Analysis of plasminogen genetic variants in multiple sclerosis.
G3: Genes/Genomes/Genetics.

Alloza I., Goikuria H., Freijo M.M. and Vandenbroeck K. (2016)
A role for autophagy in carotid aterosclerosis.
European Stroke Journal

2015

Matesanz F., Potenciano V., Fedetz M., Ramos-Mozo P., Abad-Grau M., Karaky M., Barrionuevo C., Izquierdo G., Ruiz-Peña J.L., García-Sánchez M.I., Lucas M. Fernández O., Leyva L., Otaegui D., Muñoz-Culla M., Olascoaga J., Vandenbroeck K., Alloza I., Astobi (2015)
A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis
Hum. Mol. Genet.

Lill C.M., Luessi F., Alcina A., Sokolova A.A., Ugidos N., de la Hera B., Guillot-Noël L., Malhotra S., Reinthaler E., Schjeide B.M.M., Mescheriakova J., Mashychev A., Akkad D.A., Aktas O., Alloza I., Antigüedad A., Arroyo R., Astobiza I., Blaschke P., Bo (2015)
Genome-wide significant association with seven novel multiple sclerosis loci.
J. Med. Genet.

Bustamante M.F., Morcillo-Suárez C., Malhotra S., Rio J., Leyva L., Fernández O., Zettl U.K., Killestein J., Brassat D., García-Merino A., Sánchez A.J., Urcelay E., Alvarez-Lafuente R., Villar L.M., Alvarez-Cermeño J.C., Farré X., Lechner-Scott J., Vande (2015)
Pharmacogenomic study in patients with multiple sclerosis: responders and non-responders to IFN-beta.
Neurology: Neuroimmunology & Neuroinflammation

Lopez de Lapuente A., Pinto-Medel M.J., Astobiza I., Alloza I., Comabella M., Malhotra S., Montalban X., Zettl U.K., Rodríguez-Antigüedad A., Fernández O. and Vandenbroeck K. (2015)
Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis.
Mult. Scler. J.

2014

de la Hera B., Varadé J., García-Montojo M., Alcina A., Fedetz M., Alloza I., Astobiza I., Leyva L., Fernández O., Izquierdo G., Antigüedad A., Arroyo R., Álvarez-Lafuente R., Vandenbroeck K., Matesanz F. and Urcelay E. (2014)
Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis: a meta-analysis.
PLoS One

Swaminathan B., Goikuria H., Vega R., Rodríguez-Antigüedad A., López Medina A., Freijo M.M., Vandenbroeck K. and Alloza I. (2014)
Autophagic marker MAP1LC3B expression levels are associated with carotid atherosclerosis symptomatology.
PLoS ONE

2013

Di Penta A., Moreno B., Reix S., Fernandez-Diez B., Villanueva M., Errea O., Escala N., Vandenbroeck K., Comella J.X. and Villoslada P. (2013)
Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation.
PLoS One

Alcina A, Fedetz M, Fernández O, Saiz A, Izquierdo G, Lucas M, Leyva L, García-León JA, Abad-Grau Mdel M, Alloza I, Antigüedad A, Garcia-Barcina MJ, Vandenbroeck K, Varadé J, de la Hera B, Arroyo R, Comabella M, Montalban X, Petit-Marty N, Navarro A, Otae (2013)
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.
J. Med. Genet.

Lill C.M., Schjeide B.M.M., Graetz C., Liu T., Damotte V., Akkad D.A., Blaschke P., Gerdes L.A....Zipp F., Vandenbroeck K. and Bertram L. (2013)
Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk
J. Med. Genet.

Swaminathan B, Cuapio A, Alloza I, Matesanz F, Alcina A, García-Barcina M, Fedetz M, Fernández O, Lucas M, Orpez T, Pinto-Medel MJ, Otaegui D, Olascoaga J, Urcelay E, Ortiz MA, Arroyo R, Oksenberg JR, Antigüedad A, Tolosa E, Vandenbroeck K. (2013)
Fine mapping and functional analysis of the multiple sclerosis risk gene CD6.
PLoS One

Comabella M, Caminero AB, Malhotra S, Agulló L, Fernández O, Reverter F, Vandenbroeck K, Rodríguez-Antigüedad A, Matesanz F, Izquierdo G, Urcelay E, López-Larios A, Sánchez A, Otero S, Tintoré M, Montalban X. (2013)
TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis.
Neurology

Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, ....Zettl UK, Hintzen R, Vandenbroeck K, Stewart G., Fontai (2013)
MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.
Brain

Di Penta A., Chiba A., Alloza I., Wyssenbach A., Yamamura T., Villoslada P., Miyake S. and Vandenbroeck K. (2013)
A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation.
PLoS ONE

2012

Tsareva E.Y., Kulakova O.G., Boyko A.N., Shchur S.G., Lvovs D., Favorov A.V., Gusev E.I., Vandenbroeck K. and Favorova O. (2012)
Allelic combinations of immune response genes associated with glatiramer acetate treatment response in Russian multiple sclerosis patients
Pharmacogenomics

Vandenbroeck K (2012)
Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies
Journal of Interferon and Cytokine Research

Vandenbroeck K., Alvarez J., Swaminathan B., Alloza I., Matesanz F., Ucelay E., Comabella M., Alcina A., Fedetz M., Ortiz M.A., Izquierdo G., Fernández O., Rodriguez-Ezpeleta N., Matute C., Cailler S., Arroyo R., Montalban X., Oksenberg J.R., Antigüed (2012)
A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis
Genes and Immunity

Varade J., Comabella M., Ortiz M.A., [....] , Montalban X., Vandenbroeck K. and Urcelay E. (2012)
Replication study of ten genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CLBL genes
Multiple Sclerosis Journal

Alloza I., Otaegui D., Lopez de Lapuente A., Antiguedad A., .... Vandenbroeck K. (2012)
ANKRD55 and DHCR7 are novel multiple sclerosis risk genes
Genes and Immunity

Canto E, Reverter F, Morcillo-Suarez C, Matesanz F, Fernandez O, Vandenbroeck K, Rodriguez-Antiguedad A, Urcelay E, Otaegui D, Olascoaga J, Saiz A, Navarro A, Sanchez A et al. (2012)
Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis
Multiple Sclerosis Journal

Lopez de Lapuente A., Alloza I., Goertsches R., Zetll U.K., Urcelay E. Arroyo R., Comabella M., Montalban X., Antigüedad A. and Vandenbroeck K. (2012)
Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis.
J. Neuroimmunol.

Chiba A., Mizuno M., Tomi C., Tajima R., Alloza I., di Penta A., Yamamura T., Vandenbroeck K. and Miyake S. (2012)
A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation.
Arthritis Res. Ther.

Lill C.M., Liu T., Schjeide B.M.M., Roehr J.T., Akkad D.A., Damotte V., Alcina A., Ortiz M.A., Arroyo R., ...Vandenbroeck K., Matesanz F., Urcelay E., Bertram L. and Zipp F. (2012)
Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects.
J. Med. Genet.

Kulakova O.G., Tsareva E.Y., Boyko A.N., Shchur S.G., Gusev E.I., Lvovs D., Favorov A.V., Vandenbroeck K. and Favorova O.O. (2012)
Allelic combinations of immune response genes as possible composite markers of optimal interferon-beta efficacy in multiple sclerosis patients.
Pharmacogenomics

2011

Cavanillas M.L., Fernandez O., Comabella M., Alcina A., Fedetz M., Izquierdo G., Lucas M., Cenit M.C., Arroyo R., Vandenbroeck K., Alloza I., Garci­a-Barcina M., Antiguedad A., Leyva L., Lopez-Gomez C., Olascoaga J., Otaegui D., Blanco Y., Saiz A., Mo (2011)
Replication of top markers of a genome-wide association study in multiple sclerosis in Spain
Genes and Immunity

Vandenbroeck K., Alloza I., Swaminathan B., Antiguedad A., Otaegui D., Olascoaga J., Garcia Barcina M., de las Heras V., Bartolome M., Fernandez-Arquero M., Arroyo R., Alvarez-Lafuente R., Cenit M.C. and Urcelay E. (2011)
Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus 6 infection
Genes and Immunity

McLaughlin M. and Vandenbroeck K. (2011)
The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?
British Journal of Pharmacology

Comabella M. and Vandenbroeck K. (2011)
Pharmacogenomics and multiple sclerosis: moving towards individualized medicine
Current Neurology and Neuroscience Reports

Malhotra S., Morcillo-Suarez C., Brassat D., Goertsches R., Urcelay E., Fernandez O., Drulovic J., Garci­a-Merino A., Martinelli Boneschi F., Chan A., Vandenbroeck K., Navarro A., Bustamante M.F., Rio J., Oksenberg J., Montalban X. et al. (2011)
IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis
Journal of Neuroimmunology

2010

McLaughlin M., Alloza I., Quoc P.H., Scott C.J., Hirabayashi Y. and Vandenbroeck K. (2010)
Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethylcelecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP
The Journal of Biological Chemistry

Alcina A.*, Vandenbroeck K.*, Otaegui D.*, Saiz A., Gonzalez J.R., Fernandez O., Cavanillas M.L., Cenit M.C., Arroyo R., Alloza I., Garci­a-Barcina M., Antiguedad A., Leyva L., Izquierdo G., Lucas M., Fedetz M., Pinto-Medel M.J., Olascoaga J., Blanco Y (2010)
The autoimmune-disease associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis
Genes and Immunity

Swaminathan B., Matesanz F., Cavanillas M.L., Alloza I., Otaegui D., Olascoaga J., Cénit M.C., de la Heras V., García Barcina M., Arroyo R., Alcina A., Fernandez O., Antigüedad A., Urcelay E. and Vandenbroeck K. (2010)
Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain
Journal of Neuroimmunology

Vandenbroeck K. and Comabella M. (2010)
Single-nucleotide polymorphisms in response to interferon-beta therapy in multiple sclerosis
Journal of Interferon & Cytokine Research

Vandenbroeck K., Urcelay E. and Comabella M. (2010)
Interferon-beta pharmacogenomics in multiple sclerosis
Pharmacogenomics

Burkart V., Siegenthaler R.K., Blasius E., Vandenbroeck K., Alloza I., Fingberg W., Schoot N.C., Christen P. and Kolb H. (2010)
High affinity binding of hydrophobic and autoantigenic regions of proinsulin to the 70 kDa chaperone, DnaK.
BMC Biochemistry

2009

O'Doherty C., Alloza I., Rooney M. and Vandenbroeck K. (2009)
IL7RA polymorphisms and chronic inflammatory arthropathies
Tissue Antigens

Vandenbroeck K., Comabella M., Tolosa E., Goertsches R., Brassat D., Hintzen R., Infante–Duarte C., Favorov A., Escorza S., Palacios R., Oksenberg J.R. and Villoslada P (2009)
Special Report – United Europeans for development of pharmacogenomics in multiple sclerosis network
Pharmacogenomics

O’Doherty C., Favorov A., Heggarty S., Graham C., Favorova O., Ochs M., Hawkins S., Hutchinson M., O’Rourke K. and Vandenbroeck K. (2009)
Genetic polymorphisms, their allele combinations and interferon-β treatment response in Irish multiple sclerosis patients
Pharmacogenomics

2008

Kantarci O.H., Hebrink D.D., Schaefer-Klein J., Sun Y., Achenbach S., Atkinson E.J., Heggarty S., Cotleur A.C., de Andrade M., Vandenbroeck K., Pelfrey C.M. and Weinshenker B.G. (2008)
Interferon gamma allelic variants: sex-biased multiple sclerosis susceptibility and gene expression
Archives of Neurology

Hawwa A.F., Millership J.S., Collier P.S., Vandenbroeck K., McCarthy A., Dempsey S., Cairns C., Collins J., Rodgers C. and McElnay J.C (2008)
Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine
British Journal of Pharmacology

Booth D, Heard R., Stewart G., Rioux J., Daly M., Vandenbroeck K., Barcellos L., Sawcer S., Oksenberg J. and others (IMSGC) (2008)
Refining genetic associations in multiple sclerosis
Lancet Neurology

O’Doherty C., Kantarci O.H. and Vandenbroeck K. (2008)
IL7RA polymorphisms and susceptibility to multiple sclerosis
New England Journal of Medicine

Paunović V., Carroll H.P., Vandenbroeck K. and Gadina M. (2008)
Crossed signals: the role of interleukin (IL)-12, -17, -23, and -27 in autoimmunity
Rheumatology

Vandenbroeck K. and Matute C. (2008)
Pharmacogenomics of the response to IFN-β in multiple sclerosis: ramifications from the first genome-wide screen
Pharmacogenomics

2005

Lopez de Lapuente A., Pinto-Medel M.J., Astobiza I., Alloza I., Comabella M., Malhotra S., Montalban X., Zettl U.K., Antigüedad A., Fernández O. and Vandenbroeck K. (2005)
Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis.
Multiple Sclerosis Journal

Books and book chapters

Published

  • Vandenbroeck K. and Alloza I. (2010)
    Type: chapters
    Book: Tratado de Esclerosis Multiple
    Chapter: Capi­tulo 13: Farmacogenomica
    Page numbers: 319-327
    ISBN: To be determined | Barcelona, Spain | Editors: Pablo Villoslada
  • de Andrade M., Caruso C., Gadina M., Kwok P.Y., Laitinen T., Lazarus R., Oksenberg J.R., Pociot F., Rioux J.D., Zagury J.F. and others (2006)
    Type: book
    Book: Cytokine gene polymorphisms in multifactorial conditions
    Chapter:
    Page numbers:
    ISBN: 0849336198 | Boca Raton, Florida | Editors: Koen Vandenbroeck
  • Vandenbroeck K. and Goris A. (2006)
    Type: book
    Book: Cytokine gene polymorphisms in multifactorial conditions
    Chapter: The IFNG-IL26-IL22 cytokine gene cluster
    Page numbers: 157-174
    ISBN: 0849336198 | Boca Raton, Florida | Editors: Koen Vandenbroeck
 
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