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Dr. Francisco José Blanco Gutiérrez

Dr. Francisco José Blanco Gutiérrez

Dr. Francisco José Blanco Gutiérrez
(Spain)

  • Doctor in Chemistry 1992 from the University Complutense of Madrid.
  • 15 years research experience in centres in Germany, the United States and Spain.
  • Research line: Biosciences, protein structures.
  • Comes from the National Centre for Oncological Research (CNIO) in Madrid.
  • Has joined the CIC bioGUNE in the Technological Park in Bizkaia.

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Publications

2010

Marcaida MJ, Muñoz IG, Blanco FJ, Prieto J, Montoya G (2010)
Homing endonucleases: from basics to therapeutic applications
Cellular and Molecular Life Sciences

A. López de Opakua, T. Diercks, AR Viguera & FJ Blanco (2010)
NMR assignment and backbone dynamics of the pore-forming domain of colicin A
Biomolecular NMR asignments

Palacios A, Moreno A, Oliveira BL, Rivera T, Prieto J, García P, Fernández-Fernández MR, Bernadó P, Palmero I, Blanco FJ (2010)
The Dimeric Structure and the Bivalent Recognition of H3K4me3 by the Tumor Suppressor ING4 Suggests a Mechanism for Enhanced Targeting of the HBO1 Complex to Chromatin.
Journal of Molecular Biology

Blanco FJ, Villegas S, Benitez S, Bancells C, Diercks T, Ordonez-Llanos J, Sanchez-Quesada JL. (2010)
2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles
Journal of lipid research

S. Culurgioni, I. Muñoz, A. Palacios, P. Redondo, FJ Blanco and G. Montoya (2010)
Crystallization and preliminary X-ray diffraction analysis on the dimerization domain of the tumour suppressor ING4
Acta crystallographica. Section F, Structural biology and crystallization communications

Sánchez R, Pantoja-Uceda D, Prieto J, Diercks T, Marcaida MJ, Montoya G, Campos-Olivas R, Blanco FJ (2010)
Solution Structure of Human Growth Arrest and DNA Damage 45alfa (Gadd45alfa) and its Interactions with Proliferating Cell Nuclear Antigen (PCNA) and Aurora A Kinase
Journal of Biological Chemistry

2009

AM Cuesta, D Sánchez-Martín, L Sanz, J Bonet, M Compte, L Kremer, FJ Blanco, B Oliva, and L Álvarez-Vallina (2009)
In Vivo Tumor Targeting and Imaging with Engineered Trivalent Antibody Fragments Containing Collagen-Derived Sequences
PLoS One

S Grizot, J Smith, F Daboussi, J Prieto, P Redondo, N Merino, M Villate, S Thomas, L Lemaire, G Montoya, FJ Blanco, F Pâques, P Duchateau (2009)
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
Nucleic Acids Research

2008

Palacios A, Muñoz IG, Pantoja-Uceda D, Marcaida MJ, Torres D, Martín-García JM, Luque I, Montoya G, Blanco FJ. (2008)
Molecular basis of histone H3K4ME3 recognition by ING4
Journal of Biological Chemistry

Muñoz IG, Blanco FJ. And Montoya G (2008)
On the relevance of defining protein structures in cancer research
Cliical and Translational Oncology

Pantoja-Uceda D, Arolas JL, García P, López-Hernández E, Padró D, Aviles FX, Blanco FJ. (2008)
The NMR Structure and Dynamics of the Two-Domain Tick Carboxypeptidase Inhibitor Reveal Flexibility in Its Free Form and Stiffness upon Binding to Human Carboxypeptidase B
Biochemistry

Arolas JL, Pantoja-Uceda D, Ventura, S, Blanco FJ. & Aviles FX, (2008)
The NMR structures of the major intermediates of the two-domain tick carboxypeptidase inhibitor reveal symmetry in its folding and unfolding pathways
Journal of Biological Chemistry

. L. M. Contreras, J. Gómez, J. Prieto, J.M. Clemente-Jiménez, F. J. Las Heras-Vázquez, F. Rodríguez-Vico, (2008)
The The family 52 b-xylosidase from Geobacillus stearothermophilus is a dimer: structural and biophysical characterization of a glycoside hydrolase
Biochemistry

T. Zimmerman & F. J. Blanco (2008)
Inhibitors targeting the LFA-1/ICAM-1 cell-adhesion interaction: design and mechanism of action.
Current Pharmaceutical Design

Sánchez, R., Pantoja-Uceda, D., Torres, D., Prieto, J., Campos-Olivas, R and Blanco, (2008)
NMR assignment and secondary structure of human growth arrest and DNA damage α protein (Gadd45α).
Biomolecular NMR assignments

P Redondo, J Prieto, I G. Muñoz, A Alibés, F Stricher, L Serrano, J-P Cabaniols, F Daboussi, S Arnould5, C Perez, P Duchateau, F Pâques5, F J. Blanco & G Montoya (2008)
Molecular basis of xeroderma pigmentoxum group C DNA recognition by engineered meganucleases
Nature

MJ Marcaida, J Prieto, P Redondo, AD NAdra, A Alibés, L Serrano, S Grizot, P Duchateau, F Pâques, FJ Blanco & G Montoya (2008)
The crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering
PNAS

In press

C Bancells, S Villegas, FJ Blanco, S Benítez, I Gállego, L Beloki, M Pérez-Cuellar, J Ordóñez-Llanos, JL Sánchez-Quesada (2010)
Aggregated electronegative low-density lipoprotein in human plasma shows high tendency to phospholipolysis and particle fusion
Journal of Biological Chemistry

Moreno A, Palacios, Orgaz JL, Jiménez B, Blanco FJ, Palmero I (2010)
Functional impact of cancer-associated mutations in the tumor suppressor protein ING4
Carcinogenesis

Blanco FJ, Valle M, Millet O (2010)
The Structural Challenge
Public Review Service, European Union

I GMuñoz, J Prieto, S Subramanian, J Coloma, P Redondo, M Villate, N Merino, M Marenchino, M D'Abramo, F L Gervasio, S Grizot, F Daboussi, J Smith, I Chion-Sotinel, F Pâques, P Duchateau, A Alibés, F Stricher, L Serrano, FJ Blanco, G Montoya (2010)
Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus
Nucleic Acids Res

_DOCTORAL

  • Structural and functional characterization of the N-terminal dimerization domain of ING4
  • 2006
  • Autónoma de Madrid
  • Simone Curlurgioni
  • Relación estructura-función del supresor tumoral ING4
  • 2005
  • Universidad Complutnese de Madrid
  • Alicia Palacios Ortega

Courses given

  • 2010
    Professor of the Máster Universitario en Biotecnología, Universidad Internacional de Andalucía, La Rábida.
  • 2010
    Professor of the Máster en Bioquímica y Biología Molecular, Universidad del País Vasco-Universidad de Cantabria, Santander

Managerial activities

  • Co-organizer of the V Reunión Bienal del Grupo Especializado de RMN de la Real Sociedad Española de Química.
 
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