David Albesa-Jové

Ikerbasque Research Associate, Biofisika Institute

Group Leader at Biofisika Institute.

Research line:

Structural Microbiology.

Previous research experience at CIC bioGUNE (ES), the Imperial College London and Durham University (UK).

PhD in Chemistry from the University of Birmingham (UK).

Publicaciones

2021

Article / Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells

Nature Microbiology

Nolan, L.M.; Cain, A.K.; Clamens, T.; Furniss, R.C.D.; Manoli, E.; Sainz-Polo, M.A.; Dougan, G.; Albesa-Jové, D.; Parkhill, J.; Mavridou, D.A.I.; Filloux, A. (2021)

2020

Article / The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM

Current Research in Structural Biology

Javier O Cifuente, Natalia Comino, Cecilia D’Angelo, Alberto Marina, David Gil-Carton, David Albesa-Jové, Marcelo E Guerin (2020)

Article / The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM

Current Research in Structural Biology

Cifuente, J.O.; Comino, N.; D'Angelo, C.; Marina, A.; Gil-Carton, D.; Albesa-Jové, D.; Guerin, M.E. (2020)

Article / Dissecting the Structural and Chemical Determinants of the "open-To-Closed" Motion in the Mannosyltransferase PimA from Mycobacteria

Biochemistry

Rodrigo-Unzueta, A.; Ghirardello, M.; Urresti, S.; Delso, I.; Giganti, D.; Anso, I.; Trastoy, B.; Comino, N.; Tersa, M.; D'Angelo, C.; Cifuente, J.O.; Marina, A.; Liebau, J.; Mäler, L.; Chenal, A.; Albesa-Jové, D.; Merino, P.; Guerin, M.E. (2020)

Article / Structural insights into Pseudomonas aeruginosa Type six secretion system exported effector 8

Journal of Structural Biology

González-Magaña, A.; Sainz-Polo, M.Á.; Pretre, G.; Çapuni, R.; Lucas, M.; Altuna, J.; Montánchez, I.; Fucini, P.; Albesa-Jové, D. (2020)

2019

Article / Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain

Journal of Molecular Biology

Cabrera, Y.; Dublang, L.; Fernández-Higuero, J.A.; Albesa-Jové, D.; Lucas, M.; Viguera, A.R.; Guerin, M.E.; Vilar, J.M.G.; Muga, A.; Moro, F. (2019)

Article / Structure-function relationships underlying the dual N-acetylmuramic and N-acetylglucosamine specificities of the bacterial peptidoglycan deacetylase PdaC

Journal of Biological Chemistry

Grifoll-Romero, L.; Sainz-Polo, M.A.; Albesa-Jové, D.; Guerin, M.E.; Biarnés, X.; Planas, A. (2019)

2018

Article / The Molecular Mechanism of Substrate Recognition and Catalysis of the Membrane Acyltransferase PatA from Mycobacteria

ACS Chemical Biology

Tersa, M.; Raich, L.; Albesa-Jové, D.; Trastoy, B.; Prandi, J.; Gilleron, M.; Rovira, C.; Guerin, M.E. (2018)

2017

Article / Structural Snapshots of alpha-1, 3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases

Angewandte Chemie

David Albesa-Jové*, M Ángela Sainz-Polo, Alberto Marina, Marcelo E Guerin* (corresponding author) (2017)

Article / The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis

Journal of Biological Chemistry

Rosado, L.A.; Wahni, K.; Degiacomi, G.; Pedre, B.; Young, D.; De la Rubia, A.G.; Boldrin, F.; Martens, E.; Marcos-Pascual, L.; Sancho-Vaello, E.; Albesa-Jové, D.; Provvedi, R.; Martin, C.; Makarov, V.; Versées, W.; Verniest, G.; Guerin, M.E.; Mateos, L.M.; Manganelli, R.; Messens, J. (2017)

Article / Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS

Structure

Albesa-Jové, D.; Romero-García, J.; Sancho-Vaello, E.; Contreras, F.X.; Rodrigo-Unzueta, A.; Comino, N.; Carreras-González, A.; Arrasate, P.; Urresti, S.; Biarnés, X.; Planas, A.; Guerin, M.E. (2017)

Review / Structural basis of phosphatidyl-myo-inositol mannosides biosynthesis in mycobacteria

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Sancho-Vaello, E.; Albesa-Jové, D.; Rodrigo-Unzueta, A.; Guerin, M.E. (2017)

2016

Article / Structural Basis of Glycogen Biosynthesis Regulation in Bacteria

Structure

Cifuente, J.O.; Comino, N.; Madariaga-Marcos, J.; López-Fernández, S.; García-Alija, M.; Agirre, J.; Albesa-Jové, D.; Guerin, M.E. (2016)

Article / Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

Nature Communications

Albesa-Jové, D.; Svetlíková, Z.; Tersa, M.; Sancho-Vaello, E.; Carreras-González, A.; Bonnet, P.; Arrasate, P.; Eguskiza, A.; Angala, S.K.; Cifuente, J.O.; Korduláková, J.; Jackson, M.; Mikušová, K.; Guerin, M.E. (2016)

Review / The conformational plasticity of glycosyltransferases

Current Opinion in Structural Biology

Albesa-Jové, D.; Guerin, M.E. (2016)

2015

Article / The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053

Journal of Biological Chemistry

Albesa-Jove, D.; Comino, N.; Tersa, M.; Mohorko, E.; Urresti, S.; Dainese, E.; Chiarelli, L.R.; Pasca, M.R.; Manganelli, R.; Makarov, V.; Riccardi, G.; Svergun, D.I.; Glockshuber, R.; Guerin, M.E. (2015)

Article / A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase

Angewandte Chemie - International Edition

Albesa-Jové, D.; Mendoza, F.; Rodrigo-Unzueta, A.; Gomollõn-Bel, F.; Cifuente, J.O.; Urresti, S.; Comino, N.; Gõmez, H.; Romero-García, J.; Lluch, J.M.; Sancho-Vaello, E.; Biarnés, X.; Planas, A.; Merino, P.; Masgrau, L.; Guerin, M.E. (2015)

Article / Secondary structure reshuffling modulates glycosyltransferase function at the membrane

Nature Chemical Biology

Giganti, D.; Albesa-Jové, D.; Urresti, S.; Rodrigo-Unzueta, A.; Martínez, M.A.; Comino, N.; Barilone, N.; Bellinzoni, M.; Chenal, A.; Guerin, M.E.; Alzari, P.M. (2015)

2014

Article / Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis

ACS Chemical Biology

Albesa-Jové, D.; Chiarelli, L.R.; Makarov, V.; Pasca, M.R.; Urresti, S.; Mori, G.; Salina, E.; Vocat, A.; Comino, N.; Mohorko, E.; Ryabova, S.; Pfieiffer, B.; Lopes Ribeiro, A.L.D.J.; Rodrigo-Unzueta, A.; Tersa, M.; Zanoni, G.; Buroni, S.; Altmann, K.H.; Hartkoorn, R.C.; Glockshuber, R.; Cole, S.T.; Riccardi, G.; Guerin, M.E. (2014)

Article / Structural basis of chitin oligosaccharide deacetylation

Angewandte Chemie - International Edition

Andrés, E.; Albesa-Jové, D.; Biarnés, X.; Moerschbacher, B.M.; Guerin, M.E.; Planas, A. (2014)

Review / Structure-function relationships of membrane-associated GT-B glycosyltransferases

Glycobiology

Albesa-Jové, D.; Giganti, D.; Jackson, M.; Alzari, P.M.; Guerin, M.E. (2014)

2013

Article / Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria

Journal of Biological Chemistry

Giganti, D.; Alegre-Cebollada, J.; Urresti, S.; Albesa-Jové, D.; Rodrigo-Unzueta, A.; Comino, N.; Kachala, M.; López-Fernández, S.; Svergun, D.I.; Fernández, J.M.; Guerin, M.E. (2013)

2012

Article / Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria

Journal of Biological Chemistry

Urresti, S.; Albesa-Jove, D.; Schaeffer, F.; Pham, H.T.; Kaur, D.; Gest, P.; Van Der Woerd, M.J.; Carreras-González, A.; López-Fernández, S.; Alzari, P.M.; Brennan, P.J.; Jackson, M.; Guerin, M.E. (2012)