Group Leader at Biofisika Institute.
Research line:
Structural Microbiology.Previous research experience at CIC bioGUNE (ES), the Imperial College London and Durham University (UK).
PhD in Chemistry from the University of Birmingham (UK).
David Albesa-Jové
Ikerbasque Research Associate Professor, Biofisika Institute
2025
Article / Electrophysiological dissection of the ion channel activity of the Pseudomonas aeruginosa ionophore protein toxin Tse5
Chemistry and Physics of Lipids
Jessica Rojas-Palomino, Jon Altuna-Alvarez, Amaia González-Magaña, María Queralt-Martín, David Albesa-Jové, Antonio Alcaraz
Article / Selective cargo and membrane recognition by SNX17 regulates its interaction with Retriever
EMBO Reports
Martín-González, A.; Méndez-Guzmán, I.; Zabala-Zearreta, M.; Quintanilla, A.; García-López, A.; Martínez-Lombardía, E.; Albesa-Jové, D.; Acosta, J.C.; Lucas, M.
Article / Electrophysiological dissection of the ion channel activity of the Pseudomonas aeruginosa ionophore protein toxin Tse5
Chemistry and Physics of Lipids
Rojas-Palomino, J.; Altuna-Alvarez, J.; González-Magaña, A.; Queralt-Martín, M.; Albesa-Jové, D.; Alcaraz, A.
Article / A new class of type VI secretion system effectors can carry two toxic domains and are recognized through the WHIX motif for export
Plos Biology
Fridman, C.M.; Keppel, K.; Rudenko, V.; Altuna-Alvarez, J.; Albesa-Jové, D.; Bosis, E.; Salomon, D.
Article / The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarization with K+ efflux
Plos Pathogens
Rojas-Palomino, J.; Velazquez, C.; Altuna-Alvarez, J.; Gonzalez-Magana, A.; Zabala-Zearreta, M.; Muller, M.; Queralt-Martin, M.; Alcaraz, A.; Albesa-Jove, D.
2023
Article / Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane
Nature Communications
González-Magaña, A.; Tascón, I.; Altuna-Alvarez, J.; Queralt-Martín, M.; Colautti, J.; Velázquez, C.; Zabala, M.; Rojas-Palomino, J.; Cárdenas, M.; Alcaraz, A.; Whitney, J.C.; Ubarretxena-Belandia, I.; Albesa-Jové, D.
2022
Article / The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria
Communications Biology
González-Magaña, A.; Altuna, J.; Queralt-Martín, M.; Largo, E.; Velázquez, C.; Montánchez, I.; Bernal, P.; Alcaraz, A.; Albesa-Jové, D.
Article / Fine-tuning of the Hsc70-based Human Protein Disaggregase Machinery by the Distinctive C-terminal Extension of Apg2
Journal of Molecular Biology
Cabrera, Y.; Bernardo-Seisdedos, G.; Dublang, L.; Albesa-Jové, D.; Orozco, N.; Viguera, A.R.; Millet, O.; Muga, A.; Moro, F.
2021
Article / Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells
Nature Microbiology
Nolan, L.M.; Cain, A.K.; Clamens, T.; Furniss, R.C.D.; Manoli, E.; Sainz-Polo, M.A.; Dougan, G.; Albesa-Jové, D.; Parkhill, J.; Mavridou, D.A.I.; Filloux, A.
2020
Article / The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM
Current Research in Structural Biology
Cifuente, J.O.; Comino, N.; D'Angelo, C.; Marina, A.; Gil-Carton, D.; Albesa-Jové, D.; Guerin, M.E.
Article / Dissecting the Structural and Chemical Determinants of the "open-To-Closed" Motion in the Mannosyltransferase PimA from Mycobacteria
Biochemistry
Rodrigo-Unzueta, A.; Ghirardello, M.; Urresti, S.; Delso, I.; Giganti, D.; Anso, I.; Trastoy, B.; Comino, N.; Tersa, M.; D'Angelo, C.; Cifuente, J.O.; Marina, A.; Liebau, J.; Mäler, L.; Chenal, A.; Albesa-Jové, D.; Merino, P.; Guerin, M.E.
Article / Structural insights into Pseudomonas aeruginosa Type six secretion system exported effector 8
Journal of Structural Biology
González-Magaña, A.; Sainz-Polo, M.Á.; Pretre, G.; Çapuni, R.; Lucas, M.; Altuna, J.; Montánchez, I.; Fucini, P.; Albesa-Jové, D.
2019
Article / Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain
Journal of Molecular Biology
Cabrera, Y.; Dublang, L.; Fernández-Higuero, J.A.; Albesa-Jové, D.; Lucas, M.; Viguera, A.R.; Guerin, M.E.; Vilar, J.M.G.; Muga, A.; Moro, F.
Article / Structure-function relationships underlying the dual N-acetylmuramic and N-acetylglucosamine specificities of the bacterial peptidoglycan deacetylase PdaC
Journal of Biological Chemistry
Grifoll-Romero, L.; Sainz-Polo, M.A.; Albesa-Jové, D.; Guerin, M.E.; Biarnés, X.; Planas, A.
2018
Article / The Molecular Mechanism of Substrate Recognition and Catalysis of the Membrane Acyltransferase PatA from Mycobacteria
ACS Chemical Biology
Tersa, M.; Raich, L.; Albesa-Jové, D.; Trastoy, B.; Prandi, J.; Gilleron, M.; Rovira, C.; Guerin, M.E.
2017
Article / The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis
Journal of Biological Chemistry
Rosado, L.A.; Wahni, K.; Degiacomi, G.; Pedre, B.; Young, D.; De la Rubia, A.G.; Boldrin, F.; Martens, E.; Marcos-Pascual, L.; Sancho-Vaello, E.; Albesa-Jové, D.; Provvedi, R.; Martin, C.; Makarov, V.; Versées, W.; Verniest, G.; Guerin, M.E.; Mateos, L.M.; Manganelli, R.; Messens, J.
Article / Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS
Structure
Albesa-Jové, D.; Romero-García, J.; Sancho-Vaello, E.; Contreras, F.X.; Rodrigo-Unzueta, A.; Comino, N.; Carreras-González, A.; Arrasate, P.; Urresti, S.; Biarnés, X.; Planas, A.; Guerin, M.E.
Review / Structural basis of phosphatidyl-myo-inositol mannosides biosynthesis in mycobacteria
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Sancho-Vaello, E.; Albesa-Jové, D.; Rodrigo-Unzueta, A.; Guerin, M.E.
2016
Article / Structural Basis of Glycogen Biosynthesis Regulation in Bacteria
Structure
Cifuente, J.O.; Comino, N.; Madariaga-Marcos, J.; López-Fernández, S.; García-Alija, M.; Agirre, J.; Albesa-Jové, D.; Guerin, M.E.
Article / Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA
Nature Communications
Albesa-Jové, D.; Svetlíková, Z.; Tersa, M.; Sancho-Vaello, E.; Carreras-González, A.; Bonnet, P.; Arrasate, P.; Eguskiza, A.; Angala, S.K.; Cifuente, J.O.; Korduláková, J.; Jackson, M.; Mikušová, K.; Guerin, M.E.
Review / The conformational plasticity of glycosyltransferases
Current Opinion in Structural Biology
Albesa-Jové, D.; Guerin, M.E.
2015
Article / The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053
Journal of Biological Chemistry
Albesa-Jove, D.; Comino, N.; Tersa, M.; Mohorko, E.; Urresti, S.; Dainese, E.; Chiarelli, L.R.; Pasca, M.R.; Manganelli, R.; Makarov, V.; Riccardi, G.; Svergun, D.I.; Glockshuber, R.; Guerin, M.E.
Article / A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase
Angewandte Chemie - International Edition
Albesa-Jové, D.; Mendoza, F.; Rodrigo-Unzueta, A.; Gomollõn-Bel, F.; Cifuente, J.O.; Urresti, S.; Comino, N.; Gõmez, H.; Romero-García, J.; Lluch, J.M.; Sancho-Vaello, E.; Biarnés, X.; Planas, A.; Merino, P.; Masgrau, L.; Guerin, M.E.
Article / Secondary structure reshuffling modulates glycosyltransferase function at the membrane
Nature Chemical Biology
Giganti, D.; Albesa-Jové, D.; Urresti, S.; Rodrigo-Unzueta, A.; Martínez, M.A.; Comino, N.; Barilone, N.; Bellinzoni, M.; Chenal, A.; Guerin, M.E.; Alzari, P.M.
2014
Article / Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis
ACS Chemical Biology
Albesa-Jové, D.; Chiarelli, L.R.; Makarov, V.; Pasca, M.R.; Urresti, S.; Mori, G.; Salina, E.; Vocat, A.; Comino, N.; Mohorko, E.; Ryabova, S.; Pfieiffer, B.; Lopes Ribeiro, A.L.D.J.; Rodrigo-Unzueta, A.; Tersa, M.; Zanoni, G.; Buroni, S.; Altmann, K.H.; Hartkoorn, R.C.; Glockshuber, R.; Cole, S.T.; Riccardi, G.; Guerin, M.E.
Article / Structural basis of chitin oligosaccharide deacetylation
Angewandte Chemie - International Edition
Andrés, E.; Albesa-Jové, D.; Biarnés, X.; Moerschbacher, B.M.; Guerin, M.E.; Planas, A.
Review / Structure-function relationships of membrane-associated GT-B glycosyltransferases
Glycobiology
Albesa-Jové, D.; Giganti, D.; Jackson, M.; Alzari, P.M.; Guerin, M.E.
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