José Julio Rodríguez Arellano

Ikerbasque Research Professor, EHU and Biobizkaia

Group leader of the Functional Neuroanatomy Group at the Department of Neuroscience, Faculty of Medicine, University of the Basque Country and Biobizkaia.

Research line:

Researching on the neuroanatomy and functional connectivity of neural circuits in the context of memory-related plasticity under normal and pathological conditions, investigated by in vivo and in vitro approaches.

Previous research experience in centers in Switzerland (Novartis Pharma), France (INSERM), USA (Cornell Medical College & Florida Atlantic University) and United Kingdom (The open University & The University of Manchester).

Ph.D. in Biological Sciences -Neurobiology- Cum Laude from the Complutense University of Madrid in June 1995: "Evolution of the basalocortical neuronal alterations in experimental models of Alzheimer's disease".

2024

Article / Astrocyte S100β expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer’s disease mouse model

Acta Histochemica

J.J. Rodríguez E. Gardenal, F. Zallo, A. Arrue Joan Cabot, X. Busquets

Article / Entorhinal cortex astrocytic atrophy in human frontotemporal dementia

Brain Function and structure

J. J. Rodríguez, F. Zallo, E. Gardenal, Joan Cabot and X. Busquets

Article / Astrocyte S100β expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model

Acta Histochemica

Rodríguez, J.J.; Gardenal, E.; Zallo, F.; Arrue, A.; Cabot, J.; Busquets, X.

Article / Entorhinal cortex astrocytic atrophy in human frontotemporal dementia

Brain Structure and Function

Rodríguez, J.J.; Zallo, F.; Gardenal, E.; Cabot, J.; Busquets, X.

Article / Early PSA-NCAM reduction in the dentate gyrus and impaired plasticity in the Alzheimer´s disease 3xTg-mice model

Acta Histochemica

Rodríguez, J.J.; Gardenal, E.; Zallo, F.; Cabot, J.; Busquets, X.

2023

Article / Prominent and conspicuous astrocyte atrophy in human sporadic and familial Alzheimer’s disease

Brain Structure and Function

Rodríguez, J.J.; Zallo, F.; Gardenal, E.; Cabot, J.; Busquets, X.

Article / Multilocus Genetic Profile Reflecting Low Dopaminergic Signaling Is Directly Associated with Obesity and Cardiometabolic Disorders Due to Antipsychotic Treatment

Pharmaceutics

Arrue, A.; Olivas, O.; Erkoreka, L.; Alvarez, F.J.; Arnaiz, A.; Varela, N.; Bilbao, A.; Rodríguez, J.J.; Moreno-Calle, M.T.; Gordo, E.; Marín, E.; Garcia-Cano, J.; Saez, E.; Gonzalez-Torres, M.Á.; Zumárraga, M.; Basterreche, N.

Article / Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy

Eneuro

Alvarez, F.J.; Alvarez, A.A.; Rodríguez, J.J.; Lafuente, H.; Canduela, M.J.; Hind, W.; Blanco-Bruned, J.L.; Alonso-Alconada, D.; Hilario, E.

Article / Neuroanatomical and morphometric study of S100β positive astrocytes in the entorhinal cortex during ageing in the 3xTg-Alzehimer's disease mouse model

Neuroscience Letters

Rodríguez, J.J.; Terzieva, S.; Yeh, C.Y.; Gardenal, E.; Zallo, F.; Verkhratsky, A.; Busquets, X.

2021

Review / Reflections on cerebellar neuropathology in classical scrapie

Biomolecules

Toledano-Díaz, A.; Álvarez, M.I.; Rodríguez, J.J.; Badiola, J.J.; Monzón, M.; Toledano, A.

2020

Article / Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer’s disease

Neurobiology of Aging

I. Vanzulli, M. Papanikolaou, I. Chacon De La Rocha, A. Rivera, D. Gomez Nicola, A. Verkhratsky, J.J. Rodríguez, A.M. Butt

Article / Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease

Neurobiology of Aging

Vanzulli, I.; Papanikolaou, M.; De-La-Rocha, I.C.; Pieropan, F.; Rivera, A.D.; Gomez-Nicola, D.; Verkhratsky, A.; Rodríguez, J.J.; Butt, A.M.

2019

Article / Neuroglia in Ageing. Adv. Exp. Med. Biol.

Adv. Exp. Med. Biol

A. Vekhratsky, R.Zorec, J.J. Rodríguez-Arellano

Article / Astroglia in Alzheimer´s Disease

Adv. Exp. Med. Biol.

A. Vekhratsky, V. Parpura, J.J. Rodríguez-Arellano, R.Zorec

Article / Astroglial Atrophy in Alzheimer´s Disease

Pflugers Arch

A. Vekhratsky, J.J. Rodríguez, A. Pivoriunas, R.Zorec, A. Semyanov

2018

Article / Cell-autonomous astrocytopathy in Alzheimer´s disease

Acta Physiol (Oxf)

A. Verkhratsky, J.J Rodríguez

Article / Increase in S100B-positive astrocytic profiles in the entorhinal cortex during ageing and the progression of Alzheimer´s disease

Neurobiology of Aging

E. Gardenal, F.Zallo, S. Terzieva, C.Y. Yeh, A. Verkhratsky, J.J. Rodríguez

Article / Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer´s disease mice

Neurosci Lett . 2018 Aug 10;681:19-25. doi: 10.1016/j.neulet.2018.05.027. Epub 2018 May 18.

F. Zallo, E. Gardenal, A.Verkhratsky, J.J. Rodríguez

Article / Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice

Neuroscience Letters

Zallo, F.; Gardenal, E.; Verkhratsky, A.; Rodríguez, J.J.

Editorial / Cell-autonomous astrocytopathy in Alzheimer's disease

Acta Physiologica

Verkhratsky, A.; Rodríguez, J.J.

2017

Article / Increased calcium sensing receptor in the hippocampus of triple transgenic mouse model of Alzheimer´s disease

Frontiers in Neuroscience

E. Gardenal, A. Chiarini, U. Armato, I Dal Prà, A. Verkhratsky, J.J. Rodriguez

Article / Neuroglia: Functional Paralysis and reactivity in Alzheimer´s disease and other neurodegenerative pathologies

Adv. Neurobiol.

A. Verkhratsky, R. Zorec, J.J. Rodríguez, V. Parpura

Article / Increased calcium-sensing receptor immunoreactivity in the hippocampus of a triple transgenic mouse model of Alzheimer's disease

Frontiers in Neuroscience

Gardenal, E.; Chiarini, A.; Armato, U.; Dal Prà, I.; Verkhratsky, A.; Rodríguez, J.J.

Review / Astroglial calcium signalling in Alzheimer's disease

Biochemical and Biophysical Research Communications

Verkhratsky, A.; Rodríguez-Arellano, J.J.; Parpura, V.; Zorec, R.

2016

Chapter / Glial Cell Biology: A Historical Perspective

De Vries and Boullerne

V. Parpura, J.J. Rodríguez, A. Verkhratsky

Chapter / The cellular players of Alzheimer's Disease

J.J Rodríguez Arellano, A.M. Butt and A.Verkhratsky

Article / Astrocytes in physiological ageing and Alzheimer´s disease

Neuroscience

J.J. Rodríguez-Arellano, V. Parpura, R. Zorec and A. Verkhratsky

Article / Astrogliopathology in neurodegeneration.

Eur. J. Neurodeg. Dis

A. Verkhratsky, R. Zorec, J.J. Rodríguez and V. Parpura.

Article / Neuroglia in Alzheimer´s disease: from cohort to contestant in the disease progression and its therapy

Curr Azheimer´s Res

A. Toledano, J.J. Merino, J.J. Rodríguez

Article / Expression of familial Alzheimer disease genes impairs vesicle traffic and peptide secretion in cultured astrocytes devoid of pathologic tissue environment

Cell Death Diff

M. Stenovec, Saša Trkov, Slavica Terzieva, Marko Kreft1, J.J. Rodríguez, V. Parpura, A.Verkhratsky and R. Zorec

Article / Complex and differential neuroglial responses during the progression of Alzheimer´s disease and ageing: from animal models to humans

Curr. Alzheimer´s Res

J.J. Rodríguez, A.M. Butt, E. Gardenal, V. Parpura and A. Verkhratsky

Article / Mesenchymal stem cells attenuate working memory in the 3xTg-AD mouse model of Alzheimer’s disease

Int. J. Mol. Sci

J. R?ži?ka, M. Kulijewicz-Nawrott, J.J. Rodríguez, P. Jendelová, E. Syková

Article / Pathobiology of neurodegeneration: the role for astroglia

Opera Med Physiol

A. Verkhratsky, R. Zorec, J.J. Rodríguez and V. Parpura

Article / New concepts on the functionality of the nervous system: the revolution of glial cells. Glial responses keys in the pathogenesis of diseases of SN

Anales de la Real Academia Nacional de Farmacia

A. Toledano, M.I. Alvarez, A. Toledano-Díaz, J.J. Rodríguez

Article / Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture

Neuroscience

Zorec, R.; Verkhratsky, A.; Rodríguez, J.J.; Parpura, V.

Article / Calcium signalling toolkits in astrocytes and spatio-temporal progression of alzheimer’s disease

Current Alzheimer Research

Lim, D.; Rodríguez-Arellano, J.J.; Parpura, V.; Zorec, R.; Zeidán-Chuliá, F.; Genazzani, A.A.; Verkhratsky, A.

Article / Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment

GLIA

Stenovec, M.; Trkov, S.; Lasič, E.; Terzieva, S.; Kreft, M.; Rodríguez Arellano, J.J.; Parpura, V.; Verkhratsky, A.; Zorec, R.

Article / New concepts on the functionality of the nervous system: The revolution of the glial cells. II. Glial responses keys in the pathogenesis and treatment of diseases of SN

Anales de la Real Academia Nacional de Farmacia

Toledano, A.; Álvarez, M.I.; Toledano-Díaz, A.; Rodríguez-Arellano, J.J.

Editorial / Neuroglia in alzheimer’s disease: From cohort to contestant in the disease progression and its therapy

Current Alzheimer Research

Toledano, A.; Merino, J.J.; Rodríguez, J.J.

Review / Astrocytes in physiological aging and Alzheimer's disease

Neuroscience

Rodríguez-Arellano, J.J.; Parpura, V.; Zorec, R.; Verkhratsky, A.

Review / Brain local and regional neuroglial alterations in alzheimer´s disease: Cell types, responses and implications

Current Alzheimer Research

Toledano, A.; Álvarez, M.I.; Toledano-Díaz, A.; Merino, J.J.; Rodríguez, J.J.

Review / Complex and differential glial responses in alzheimer´s disease and ageing

Current Alzheimer Research

Rodríguez, J.J.; Butt, A.M.; Gardenal, E.; Parpura, V.; Verkhratsky, A.

Review / Astroglia dynamics in ageing and Alzheimer's disease

Current Opinion in Pharmacology

Verkhratsky, A.; Zorec, R.; Rodríguez, J.J.; Parpura, V.

2015

Chapter / Brain Mapping: An Encyclopedic Reference

A. Verkhratsky, A. Butt, J.J. Rodriguez and V. Parpura

Article / Deletion of GIRK2 subunit of GIRK channels alters the 5-HT1A receptor-mediated signaling and results in a depression-resistant behavior

International Journal of Neuropsychopharmacology

Llamosas, N.; Bruzos-Cidón, C.; Rodríguez, J.J.; Ugedo, L.; Torrecilla, M.

Article / Microglial response to Alzheimer’s disease is differentially modulated by voluntary wheel running and enriched environments

Brain Structure and Function

Rodríguez, J.J.; Noristani, H.N.; Verkhratsky, A.

Review / Glial Asthenia and Functional Paralysis: A New Perspective on Neurodegeneration and Alzheimers Disease

Neuroscientist

Verkhratsky, A.; Marutle, A.; Rodríguez-Arellano, J.J.; Nordberg, A.

2014

Article / Activation of retinal glia in a triple transgenic mouse model of Alzheimer’s disease

Experimental Eye Research

M. M. Edwards, J. J. Rodríguez, R. Gutierrez Lanza, J. Yates, A. Verkhratsky and G. A. Lutty

Article / Astrogliopathology: A central element of neuropsychiatric diseases?

Neuroscientist

Verkhratsky, A.; Rodríguez, J.J.; Steardo, L.

Article / Retinal macroglia changes in a triple transgenic mouse model of Alzheimer's disease

Experimental Eye Research

Edwards, M.M.; Rodríguez, J.J.; Gutierrez-Lanza, R.; Yates, J.; Verkhratsky, A.; Lutty, G.A.

Article / Altered neuronal activity and differential sensitivity to acute antidepressants of locus coeruleus and dorsal raphe nucleus in Wistar Kyoto rats: A comparative study with Sprague Dawley and Wistar rats

European Neuropsychopharmacology

Bruzos-Cidón, C.; Miguelez, C.; Rodríguez, J.J.; Gutiérrez-Lanza, R.; Ugedo, L.; Torrecilla, M.

Article / Multiple spine boutons are formed after long-lasting LTP in the awake rat

Brain Structure and Function

Medvedev, N.I.; Dallérac, G.; Popov, V.I.; Rodriguez Arellano, J.J.; Davies, H.A.; Kraev, I.V.; Doyère, V.; Stewart, M.G.

Article / Complex and region-specific changes in astroglial markers in the aging brain

Neurobiology of Aging

Rodríguez, J.J.; Yeh, C.Y.; Terzieva, S.; Olabarria, M.; Kulijewicz-Nawrot, M.; Verkhratsky, A.

Review / Neuroglia in ageing and disease

Cell and Tissue Research

Verkhratsky, A.; Rodríguez, J.J.; Parpura, V.

2013

Article / Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric AÎ²-treated astrocytes and in a model of Alzheimerâ€™s disease

Aging Cell

E. Alberdi, A. Wyssenbach, M. Alberdi, M.V. Sánchez-Gómez1, F. Cavaliere, J.J Rodríguez, A. Verkhratsky, Carlos Matute

Article / Amyloid-? and Alzheimer´s disease type pathology differentially affects calcium signalling toolkit in astrocytes from different brain regions

Cell Death and Disease

A.A. Grolla, J.A. Sim, D. Lim, J.J. Rodríguez, A.A. Genazzani, A. Verkhratsky

Article / Glutamine synthetase in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer's disease is not affected by pathological progression

Biogerontology

Yeh, C.Y.; Verkhratsky, A.; Terzieva, S.; Rodríguez, J.J.

Article / Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment

Biogerontology

Fiol-Deroque, M.A.; Gutierrez-Lanza, R.; Terés, S.; Torres, M.; Barceló, P.; Rial, R.V.; Verkhratsky, A.; Escribá, P.V.; Busquets, X.; Rodríguez, J.J.

Article / Astrocytes and glutamate homoeostasis in Alzheimer's disease: A decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortex

ASN Neuro

Kulijewicz-Nawrot, M.; Syková, E.; Chvátal, A.; Verkhratsky, A.; Rodríguez, J.J.

Article / Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease

Neuroscience Letters

Rodríguez, J.J.; Noristani, H.N.; Hilditch, T.; Olabarria, M.; Yeh, C.Y.; Witton, J.; Verkhratsky, A.

Article / Amyloid-b and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

Cell Death and Disease

Grolla, A.A.; Sim, J.A.; Lim, D.; Rodriguez, J.J.; Genazzani, A.A.; Verkhratsky, A.

Letter / Enriched environment and physical activity reverse astrogliodegeneration in the hippocampus of AD transgenic mice

Cell Death and Disease

Rodríguez, J.J.; Terzieva, S.; Olabarria, M.; Lanza, R.G.; Verkhratsky, A.

Review / Astroglia in neurological diseases

Future Neurology

Verkhratsky, A.; Rodríguez, J.J.; Parpura, V.

2012

Chapter / Research Progress in Alzheimerâ€™s Disease and Dementia

Miao-Kun Sun

J.J. Rodriguez, A. Verkhratsky

Chapter / Wiring the Brain

Eliana Scemes and David C. Spray

José Julio Rodriguez Arellano, Carlos Matute, Alexei Verkhratsky

Article / Oligomers of Î²-amyloid peptides induce selective synaptotoxicity of excitatory synapses

Neuron

F. Léveillé, J. B. Ortega, J.J. Rodríguez, R.S. Meadows, A. Verkhratsky, O. Nicole and Alain Buisson.

Article / High tryptophan diet reduces CA1 intraneuronal ?-amyloid in the triple transgenic mouse model of Alzheimer’s disease

Aging Cell

H.N. Noristani, A. Verkhratsky, JJ Rodríguez

Article / High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease

Aging Cell

Noristani, H.N.; Verkhratsky, A.; Rodríguez, J.J.

Article / Projections of the central medial nucleus of the thalamus in the rat: Node in cortical, striatal and limbic forebrain circuitry

Neuroscience

Vertes, R.P.; Hoover, W.B.; Rodriguez, J.J.

Article / Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease

Journal of Anatomy

Kulijewicz-Nawrot, M.; Verkhratsky, A.; Chvátal, A.; Syková, E.; Rodríguez, J.J.

Article / GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease

PLoS ONE

Kamphuis, W.; Mamber, C.; Moeton, M.; Kooijman, L.; Sluijs, J.A.; Jansen, A.H.P.; Verveer, M.; de Groot, L.R.; Smith, V.D.; Rangarajan, S.; Rodríguez, J.J.; Orre, M.; Hol, E.M.

Review / Neurotransmitters and integration in neuronal-astroglial networks

Neurochemical Research

Verkhratsky, A.; Rodríguez, J.J.; Parpura, V.

Review / The serotonergic system in ageing and Alzheimer's disease

Progress in Neurobiology

Rodríguez, J.J.; Noristani, H.N.; Verkhratsky, A.

Review / Neurological diseases as primary gliopathies: A reassessment of neurocentrism

ASN Neuro

Verkhratsky, A.; Sofroniew, M.V.; Messing, A.; deLanerollei, N.C.; Rempe, D.; Rodríguez, J.J.; Nedergaard, M.

Review / Calcium signalling in astroglia

Molecular and Cellular Endocrinology

Verkhratsky, A.; Rodríguez, J.J.; Parpura, V.

2011

Article / Voluntary running and environmental enrichment restores impaired hippocampal neurogenesis in a triple transgenic mouse model of Alzheimerâ€™s disease.

Curr Alzheimerâ€™s Res.

J.J. Rodríguez, H.N. Noristani, M. Olabarria, J. Fletcher, T. Summerville, C.Y. Yeh, A. Verkhratsky

Article / Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer\'s disease

ASN Neuro

C.Y. Yeh, A. Verkhratsky, J.J. Rodríguez.

Article / Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease

ASN Neuro

Yeh, C.Y.; Vadhwana, B.; Verkhratsky, A.; Rodríguez, J.J.

Article / Voluntary running and environmental enrichment restores impaired hippocampal neurogenesis in a triple transgenic mouse model of Alzheimer's disease

Current Alzheimer Research

Rodríguez, J.J.; Noristani, H.N.; Olabarria, M.; Fletcher, J.; Somerville, T.D.D.; Yeh, C.Y.; Verkhratsky, A.

Article / Anatomical study of serotonergic innervation and 5-HT1A receptor in the human spinal cord

Cell Death and Disease

Perrin, F.E.; Gerber, Y.N.; Teigell, M.; Lonjon, N.; Boniface, G.; Bauchet, L.; Rodriguez, J.J.; Hugnot, J.P.; Privat, A.M.

Article / Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: An ultrastructural study

Cell Death and Disease

Noristani, H.N.; Meadows, R.S.; Olabarria, M.; Verkhratsky, A.; Rodríguez, J.J.

Article / Serotonergic projections and serotonin receptor expression in the reticular nucleus of the thalamus in the rat

Synapse

Rodríguez, J.J.; Noristani, H.N.; Hoover, W.B.; Linley, S.B.; Vertes, R.P.

Article / Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?

Molecular Neurodegeneration

Olabarria, M.; Noristani, H.N.; Verkhratsky, A.; Rodríguez, J.J.

Review / Neurogenesis in Alzheimer's disease

Journal of Anatomy

Rodríguez, J.J.; Verkhratsky, A.

Review / Where the thoughts dwell: The physiology of neuronal-glial "diffuse neural net"

Brain Research Reviews

Verkhratsky, A.; Parpura, V.; Rodríguez, J.J.

Review / Neuroglial roots of neurodegenerative diseases?

Molecular Neurobiology

Rodríguez, J.J.; Verkhratsky, A.

2010

Article / A subpopulation of serotonin (1B) receptors colocalize with AMPA receptor subunit GluR2 in the hippocampal dentate gyrus

Neurosci Lett.

C.J. Peddie, H.A. Davies, F.M. Colyer, M.G. Stewart and J.J Rodríguez.

Article / Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-d-aspartate receptor antagonist CPP

Neuroscience

Medvedev, N.I.; Popov, V.I.; Dallérac, G.; Davies, H.A.; Laroche, S.; Kraev, I.V.; Rodriguez Arellano, J.J.; Doyère, V.; Stewart, M.G.

Article / Astrocytes in Alzheimer's Disease

Neurotherapeutics

Verkhratsky, A.; Olabarria, M.; Noristani, H.N.; Yeh, C.Y.; Rodriguez, J.J.

Article / Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease

European Journal of Neuroscience

Noristani, H.N.; Olabarria, M.; Verkhratsky, A.; Rodríguez, J.J.

Article / Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease

GLIA

Olabarria, M.; Noristani, H.N.; Verkhratsky, A.; Rodríguez, J.J.

Article / Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

Cell Death and Disease

Rodríguez, J.J.; Witton, J.; Olabarria, M.; Noristani, H.N.; Verkhratsky, A.

Review / Neuroglia in neurodegeneration

Brain Research Reviews

Heneka, M.T.; Rodríguez, J.J.; Verkhratsky, A.

Review / Glial calcium and diseases of the nervous system

Cell Calcium

Nedergaard, M.; Rodríguez, J.J.; Verkhratsky, A.

Short Survey / The Achilles heel of γ-secretase: Can we contain Alzheimer's disease by reducing synthesis of β-amyloid?

Acta Pharmacologica Sinica

Verkhratsky, A.; Rodríguez, J.J.

Calcium Sensing Receptor, Calcium Binding Proteins and astrocytic changes in Alzheimer’s disease

Universita' degli studi di Verona and University of the Basque Country

Emanuela Gardenal - Finished

Cortical astroglial atrophy in ageing and Alzheimer´s disease

University of Manchester

Chia-Yu Yeh - Finished

Astrocytic changes during the progression of Alzheimer´s disease in the mouse prefrontal cortex

Prague Charles University

Magdalena Kulijewicz-Nawrot - Finished

Altered serotonergic neurotrasnmission as a main player in the pathophysiology of Alzheimer´s disease :structural and ultrastructural studies in a triple transgenic mouse model of the disease

University of Manchester

Harun Najib Noristani - Finished

Pathophysiological adaptation and role of astrocytes in Alzheimer's disease: a longitudinal analysis in a triple transgenic mouse model

The University of Manchester

Markel Olabarria Larizgoitia - Finished

2011

Neuroglial alterations and plasticity during the progression of AlzheimerÂ´s diseaseâ€. Instituto de BiologÃa y Medicina Experimental (CONICET). Buenos Aires, Argentina.

â€œNeurogenic impairments and recovery in AlzheimerÂ´s disease: a new therapeutical target?â€. Departamento de QuÃmica BiolÃ³gica, Fac de Ciencias Exactas y Naturales, Universidad de Buenos Aires. Buenos Aires, Argentina.

â€œNeuronal and Neuroglial changes during the progresiÃ³n of AlzheimerÂ´s disease: pathological vs. plastic potential â€. Glia Day. Center for Translational Neuromedicine. The University of Rochester. NY, USA.

Neurogenic changes during the progression of AlzheimerÂ´s disease and its therapeutical potentialâ€. Biodonostia. San Sebastian

â€œNeuroglial alterations during the progression of Alzheimer's diseaseâ€. The Netherlands Institute for Neuroscience. Amsterdam, Netherlands.

2010

â€œAstroglial atrophy and microglial recruitment during the progression of Alzheimer's diseaseâ€. Birmingham, AL. USA.

â€œNeuronal and Glial alterations and interactions during the progression of Alzheimerâ€™s diseaseâ€. Biophysics Society. Bilbao.

â€œDifferential neurogenic impairment during the progression of Alzheimerâ€™s diseaseâ€. Institute for Neurosciences. Montpellier, France

â€œNew players in the Progression of Alzheimerâ€™s diseaseâ€. San Sebastian Hospital. San Sebastian.

2021

Poster presentation | Global Astrocytic Atrophy in Sporadic and Familiar Alzheimer´s Disease

J.J. Rodríguez, F. Zallo, E. Gardenal, A. Verkhratsky.

2016

Poster presentation | Expression of Calcium-Sensing Receptor (CaSR) in hippocampus increases during the progression of Alzheimer´s disease in the triple transgenic mouse model

Forum of European Neuroscience Society Meeting - Poster presentation

E. Gardenal, A. Verkhratsky, J.J. Rodríguez

2015

Conference organization | Morphological and metabolical changes in neuroglia during the progression of Alzheimer´s disease and ageing

Morphological and metabolical changes in neuroglia during the progression of Alzheimer´s disease and ageing - Conference organization

J.J. Rodríguez

Invited talk | Astroglial complex senescent phenotype and its contribution to neurodegeneration

XII European Meeting on Glial Cells in Health and Disease - Invited talk

J.J. Rodríguez

Poster presentation | Culinotherapy in Alzheimer’s disease: new strategies and insights for associate non-pharmacological therapies

25th Alzheimer Europe Conference - Poster presentation

J. J. Rodríguez Arellano, L. de la Pisa Niño, N. Marcos Muñoz, N. Villaverde Gonzalez, F. de Juan Diéguez, and A. Alvarez Roza

2014

Conference organization | Revealing the prominent role of neuroglia in neurodegeneration

FEPS Forum of European Physiology Society Meeting - Conference organization

J.J.Rodriguez

Invited talk | Complex neuroglial alterations during the progression of Alzheimer ?s disease and ageing

International Scientific School “Frontiers in Modern Neuroscience" - Invited talk

J.J Rodríguez

Invited talk | Neuroglial morphological and metabolical alterations during the progression of Alzheimer´s disease and ageing

FEPS Forum of European Physiology Society Meeting - Invited talk

J.J. Rodriguez

Poster presentation | Hypertrophy of S100ß-POSITIVE astrocytic profiles in the Mouse model of Alzheimer´s disease

9th FENS Forum of European Neuroscience Society Meeting - Poster presentation

J.J. Rodríguez Arellano, S. Terzieva, C.Y. Yeh and A. Verkhratsky

2013

Poster presentation | Changes of the extracellular space diffusion parameters during aging in a triple transgenic animal model of Alzheimer’s disease

XI European Meeting on Glial Cells in Health and Disease - Poster presentation

M. Cicanic, L. Vargova, M.Kulijewicz-Nawrot, J.J. Rodríguez, Eva Sykova

Poster presentation | Enriched environment and physical activity reverse astroglial atrophy in the hippocampus of the triple-transgenic model of AD

XI European Meeting on Glial Cells in Health and Disease - Poster presentation

J.J Rodríguez, S. Terzieva, M. Olabarria, A.Verkhratsky

2012

Oral presentation | Different effects of Amyloid-? on entorhinal cortex and hippocampal astrocytes in culture

Different effects of Amyloid-? on entorhinal cortex and hippocampal astrocytes in culture - Oral presentation

A.A. Grolla, A.A. Genazzani, P.L Canonico, J.J. Rodríguez, J.A. Sim, A. Verkhratsky

Poster presentation | Astrocytic morphological and functional alterations in the prefrontal cortex during the progression of Alzheimer’s disease in the 3xTG-AD animal model.

8th Forum of European Neuroscience - Poster presentation

M. Kulijewicz-Nawrot, E. Syková, A. Verkhratsky, J.J. Rodríguez

2011

Conference organization | Reflexiones en Neurociencia: Integración y Desintegración del Cerebro / Reflexions in Neuroscience: Integration and Desintegration of the Brain.

Reflexiones en Neurociencia: Integración y Desintegración del Cerebro / Reflexions in Neuroscience: Integration and Desintegration of the Brain. - Conference organization

J.J. Rodríguez, A. Verkhratsky.

Invited talk | Astrocytes and Alzheimerâ€™s disease

10th European meeting on glial cells in health and disease. - Invited talk

J.J. Rodríguez

Invited talk | Neuroglial role in the development and progress of AlzheimerÂ´s disease: from God to Evil

10th European meeting on glial cells in health and disease - Invited talk

J.J. Rodríguez

Invited talk | Calcium signalling in neuroglia

Joint Congress of FEPS and Turkish Society of Physiological Science - Invited talk

A. Verkhratsky, J.J. Rodríguez, V. Parpura

Invited talk | Chemical transmission in neuronal-glial networks

Joint Congress of FEPS and Turkish Society of Physiological Science - Invited talk

A. Verkhratsky, J.J. Rodríguez, V. Parpura

Invited talk | The forgotten and dark side of AlzheimerÂ´s Disease: Neuroglial Pathology

Joint Congress of FEPS and Turkish Society of Physiological Science - Invited talk

J.J. Rodríguez

Invited talk | New key players in the progression of Alzheimer's disease and its therapeutics

BIT's 2nd Annual World Congress of NeuroTalk - Invited talk

J.J. Rodríguez

Oral presentation | Neuroglial alterations in neurodegeneration

Reflexiones en Neurociencia: Integración y Desintegración del Cerebro / Reflexions in Neuroscience: Integration and Disintegration of the Brain - Oral presentation

J.J. Rodríguez

Oral presentation | Living with Alzheimerâ€™s and neuroscience: Transfer of the basic findings to the clinical and care application in the treatment of Alzheimer's disease

Reflexiones en Neurociencia: Integración y Desintegración del Cerebro / Reflexions in Neuroscience: Integration and Desintegration of the Brain. - Oral presentation

J.J. Rodríguez

Oral presentation | Living with Alzheimerâ€™s and neuroscience: Fundamental aspects of basic research into Alzheimerâ€™s disease

Reflexiones en Neurociencia: Integración y Desintegración del Cerebro / Reflexions in Neuroscience: Integration and Desintegration of the Brain. - Oral presentation

J.J. Rodríguez

Oral presentation | Ionotropic receptors in astroglia

Joint Conference of Czech and Slovak Neuroscience Societies - Oral presentation

J.J. Rodríguez

Oral presentation | Neuroglial and neurogenic alterations during the progression of Alzheimerâ€™s disease

Joint Conference of Czech and Slovak Neuroscience Societies - Oral presentation

J.J. Rodríguez

Poster presentation | Alzheimer's disease associated neuroglia and neurogenic alterations

41st Annual Meeting of the Society for Neuroscience. - Poster presentation

J.J. Rodríguez, A. Verkhratsky.

Poster presentation | Neurogenesis: A New Key Player in the Progression of Alzheimerâ€™s Disease and its Therapeutics

11th Alzheimerâ€™s Association International Conference on Alzheimerâ€™s Disease - Poster presentation

Rodríguez J.J, Yeh CY, Olabarria M., Noristani H.N., Verkhratsky A.

2010

Oral presentation | The dark side of Alzheimerâ€™s disease: might be the light at the end of the tunnel?

Biogune/Ikerbasque Annual Meeting - Oral presentation

J.J. Rodríguez

2009

Poster presentation | Increased hippocampal serotonin transporter protein in a triple trangenic model of Alzhemierâ€™s disease

39th Annual Meeting of the Society for Neuroscience - Poster presentation

Noristani H., Olabarria M., Verkhratsky A., Rodríguez J.J.