Raul Perez-Jimenez

Ikerbasque Research Professor, CIC bioGUNE

Ikerbasque Research Professor at CIC bioGUNE

Research line:

Single-molecule atomic force microscopy. Research on protein mechanics and mechanoenzymology.

Previous research experience at University of Maryland and Columbia University (United States of America) and CIC nanoGUNE

Ph.D. in Chemistry (2005), University of Granada.

2025

Article / Growing Hybrid Cuticles: Metallochitins as an Emerging Family of Bioactive Mimics of Chitin

ACS Applied Materials and Interfaces

Ashurbekova, K.; Alonso-Lerma, B.; Ashurbekova, K.; Muriqi, A.; Barandiaran, L.; Janković, I.S.; Modin, E.; Santos, J.I.; Perez-Jimenez, R.; Petravić, M.; Nolan, M.; Knez, M.

Article / Impact of loosenins on the enzymatic preparation of cellulose nanocrystals

Carbohydrate Polymers

Jabalera, Y.; Dahiya, D.; Cencerrado, C.D.O.; Caballero, A.J.; Zaldua, N.; Eceiza, A.; Master, E.R.; Perez-Jimenez, R.

2024

Article / High-throughput virtual search of small molecules for controlling the mechanical stability of human CD4

Journal of Biological Chemistry

Reifs, A.; Fernandez-Calvo, A.; Alonso-Lerma, B.; Schönfelder, J.; Franco, D.; Ortega-Muñoz, M.; Casares, S.; Jimenez-Lopez, C.; Saa, L.; Cortajarena, A.L.; De Sancho, D.; San Sebastian, E.; Perez-Jimenez, R.

Article / The strongest protein binder is surprisingly labile

Protein Science

Fernandez-Calvo, A.; Reifs, A.; Saa, L.; Cortajarena, A.L.; De Sancho, D.; Perez-Jimenez, R.

Article / A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection

Nature Biotechnology

Jabalera, Y.; Tascón, I.; Samperio, S.; López-Alonso, J.P.; Gonzalez-Lopez, M.; Aransay, A.M.; Abascal-Palacios, G.; Beisel, C.L.; Ubarretxena-Belandia, I.; Perez-Jimenez, R.

2023

Article / Compliant mechanical response of the ultrafast folding protein EnHD under force

Communications Physics

Reifs, A.; Ruiz Ortiz, I.; Saa, A.O.; Schönfelder, J.; De Sancho, D.; Muñoz, V.; Perez-Jimenez, R.

Article / Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins

Nature Microbiology

Alonso-Lerma, B.; Jabalera, Y.; Samperio, S.; Morin, M.; Fernandez, A.; Hille, L.T.; Silverstein, R.A.; Quesada-Ganuza, A.; Reifs, A.; Fernández-Peñalver, S.; Benitez, Y.; Soletto, L.; Gavira, J.A.; Diaz, A.; Vranken, W.; Sanchez-Mejias, A.; Güell, M.; Mojica, F.J.M.; Kleinstiver, B.P.; Moreno-Pelayo, M.A.; Montoliu, L.; Perez-Jimenez, R.

2022

Article / Biocompatible Silicon-Based Hybrid Nanolayers for Functionalization of Complex Surface Morphologies

ACS Applied Nano Materials

Ashurbekova, K.; Ashurbekova, K.; Alonso-Lerma, B.; Šarić, I.; Barandiaran, L.; Modin, E.; Petravić, M.; Perez-Jimenez, R.; Knez, M.

Article / Enzymatic upgrading of nanochitin using an ancient lytic polysaccharide monooxygenase

Communications Materials

Barandiaran, L.; Alonso-Lerma, B.; Reifs, A.; Larraza, I.; Olmos-Juste, R.; Fernandez-Calvo, A.; Jabalera, Y.; Eceiza, A.; Perez-Jimenez, R.

Article / Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics

Redox Biology

Herrero-Galán, E.; Martínez-Martín, I.; Sánchez-González, C.; Vicente, N.; Bonzón-Kulichenko, E.; Calvo, E.; Suay-Corredera, C.; Pricolo, M.R.; Fernández-Trasancos, Á.; Velázquez-Carreras, D.; Careaga, C.B.; Abdellatif, M.; Sedej, S.; Rainer, P.P.; Giganti, D.; Pérez-Jiménez, R.; Vázquez, J.; Alegre-Cebollada, J.

Article / Unraveling the molecular determinants of the anti-phagocytic protein cloak of plague bacteria

Plos Pathogens

Peters, D.T.; Reifs, A.; Alonso-Caballero, A.; Madkour, A.; Waller, H.; Kenny, B.; Perez-Jimenez, R.; Lakey, J.H.

2021

Article / Enzymatically produced cellulose nanocrystals as reinforcement for waterborne polyurethane and its applications

Carbohydrate Polymers

Alonso-Lerma, B.; Larraza, I.; Barandiaran, L.; Ugarte, L.; Saralegi, A.; Corcuera, M.A.; Perez-Jimenez, R.; Eceiza, A.

2020

Article / High performance crystalline nanocellulose using an ancestral endoglucanase

Communication Materials

Borja Alonso-Lerma, Leire Barandiaran, Lorena Ugarte, Izaskun Larraza, Antonio Reifs, Raquel Olmos-Juste, Nerea Barruetabeña, Iban Amenabar, Rainer Hillenbrand, Arantxa Eceiza, Raul Perez-Jimenez

Article / High performance crystalline nanocellulose using an ancestral endoglucanase

Communications Materials

Alonso-Lerma, B.; Barandiaran, L.; Ugarte, L.; Larraza, I.; Reifs, A.; Olmos-Juste, R.; Barruetabeña, N.; Amenabar, I.; Hillenbrand, R.; Eceiza, A.; Perez-Jimenez, R.

Article / Entropic bonding of the type 1 pilus from experiment and simulation

Royal Society Open Science

Corsetti, F.; Alonso-Caballero, A.; Poly, S.; Perez-Jimenez, R.; Artacho, E.

Article / Waterborne polyurethane and graphene/graphene oxide-based nanocomposites: Reinforcement and electrical conductivity

Express Polymer Letters

Larraza, I.; Alonso-Lerma, B.; Gonzalez, K.; Gabilondo, N.; Perez-Jimenez, R.; Corcuera, M.A.; Arbelaiz, A.; Eceiza, A.

2019

Article / Resurrection of efficient Precambrian endoglucanases for lignocellulosic biomass hydrolysis

Communications Chemistry

Barruetabeña, N.; Alonso-Lerma, B.; Galera-Prat, A.; Joudeh, N.; Barandiaran, L.; Aldazabal, L.; Arbulu, M.; Alcalde, M.; De Sancho, D.; Gavira, J.A.; Carrion-Vazquez, M.; Perez-Jimenez, R.

2018

Article / Mechanical architecture and folding of E. coli type 1 pilus domains

Nature Communications

Alonso-Caballero, A.; Schönfelder, J.; Poly, S.; Corsetti, F.; De Sancho, D.; Artacho, E.; Perez-Jimenez, R.

Article / Instrumental Effects in the Dynamics of an Ultrafast Folding Protein under Mechanical Force

Journal of Physical Chemistry B

De Sancho, D.; Schönfelder, J.; Best, R.B.; Perez-Jimenez, R.; Muñoz, V.

Article / Reversible two-state folding of the ultrafast protein gpW under mechanical force

Communications Chemistry

Schönfelder, J.; De Sancho, D.; Berkovich, R.; Best, R.B.; Muñoz, V.; Perez-Jimenez, R.

Review / The life of proteins under mechanical force

Chemical Society Reviews

Schönfelder, J.; Alonso-Caballero, A.; De Sancho, D.; Perez-Jimenez, R.

2017

Article / The influence of disulfide bonds on the mechanical stability of proteins is context dependent

Journal of Biological Chemistry

Manteca, A.; Alonso-Caballero, Á.; Fertin, M.; Poly, S.; de Sancho, D.; Perez-Jimenez, R.

Article / Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins

Nature Structural and Molecular Biology

Manteca, A.; Schönfelder, J.; Alonso-Caballero, A.; Fertin, M.J.; Barruetabeña, N.; Faria, B.F.; Herrero-Galán, E.; Alegre-Cebollada, J.; De Sancho, D.; Perez-Jimenez, R.

2016

Article / A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution

Nature Communications

Schönfelder, J.; Perez-Jimenez, R.; Muñoz, V.

Review / The Power of Force: Insights into the Protein Folding Process Using Single-Molecule Force Spectroscopy

Journal of Molecular Biology

Schönfelder, J.; De Sancho, D.; Perez-Jimenez, R.

2015

Article / Monitoring oxidative folding of a single protein catalyzed by the disulfide oxidoreductase DsbA

Journal of Biological Chemistry

Kahn, T.B.; Fernández, J.M.; Perez-Jimenez, R.

2014

Article / Probing the effect of force on HIV-1 receptor CD4

ACS Nano

Perez-Jimenez, R.; Alonso-Caballero, A.; Berkovich, R.; Franco, D.; Chen, M.W.; Richard, P.; Badilla, C.L.; Fernandez, J.M.

2016

Búsqueda de compuestos mecanoactivos para el control de la mecánica del receptor CD4 del virus de la inmunodeficiencia humana (VIH-1)

Basque Country

2015

Ancestral thioredoxins for nanotechnology

Basque Country

2014

Ancestral cellulases for bioenergy

Basque Country

2017

Oral presentation | Conversion of an Ultrafast Downhill Folding Protein into a Slow Two-State Folder by Mechanical Force

1st Biology for Physics: Is there new Physics in Living Matter? - Oral presentation

Raul Perez-Jimenez

2013

Invited talk | Molecular nanomechanics in human health

Imaginenano 2013 - Invited talk

Raul Perez-Jimenez