Molecular mechanism of PCNA protein sliding on DNA

CIC bioGUNE researcher Nekane Merino and Francisco Blanco, Ikerbasque Research Professor at CIC bioGUNE, in collaboration with scientists from the Elettra Sincrotrone Research Centre and the Institute of Advanced Chemistry of Catalonia have worked together on a study published in Nature Communications under the title “Structural basis of human PCNA sliding on DNA”.

Identifying the mechanism of PCNA sliding on DNA enables us to understand the functional effect of mutations in PCNA. Furthermore, this same mechanism would suggest that modulator molecules of sliding could be used as functional inhibitors. In the long term, the research may help to uncover PCNA inhibitors potentially useful for cancer treatment.

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