Iban Ubarretxena Belandia

Ikerbasque Research Professor, Director at Biofisika Institute (EHU-CSIC)

Scientific Director and Group Leader at Biofisika Institute (EHU-CSIC).

Research line:

Structural Biology of Neurodegenerative Disorders; cryo-EM of Macromolecular Complexes; Membrane Enzymology

National Science Foundation CAREER award (USA)

Post-doctoral Fellow at Yale University (USA) and MRC Laboratory of Molecular Biology (UK)

PhD in Biochemistry

2025

Article / The minimal chemotactic cell.

Science Advances

Borges-Fernandes B, Apriceno A, Arango-Restrepo A, Almadhi S, Ghosh S, Forth J, López-Alonso JP, Ubarretxena-Belandia I, Rubi JM, Ruiz-Pérez L, Williams I, Battaglia G.

Article / Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1

Nature Communications

Paula Polonio, Jorge Pedro López-Alonso, Hanxing Jiang, Sara Andrés-Campos, Fátima C. Escobedo-González, Gustavo A. Titaux-Delgado, Iban Ubarretxena-Belandia, Miguel Mompeán

Article / A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection

Nature Biotechnology

Jabalera, Y.; Tascón, I.; Samperio, S.; López-Alonso, J.P.; Gonzalez-Lopez, M.; Aransay, A.M.; Abascal-Palacios, G.; Beisel, C.L.; Ubarretxena-Belandia, I.; Perez-Jimenez, R.

Article / The minimal chemotactic cell

Science Advances

Borges-Fernandes, B.; Apriceno, A.; Arango-Restrepo, A.; Almadhi, S.; Ghosh, S.; Forth, J.; López-Alonso, J.P.; Ubarretxena-Belandia, I.; Rubi, J.M.; Ruiz-Pérez, L.; Williams, I.; Battaglia, G.

2024

Article / Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

Nature Structural and Molecular Biology

Malik, R.; Johnson, R.E.; Ubarretxena-Belandia, I.; Prakash, L.; Prakash, S.; Aggarwal, A.K.

Article / Purification of functional recombinant human mitochondrial Hsp60

Methods in Enzymology

Weiss, C.; Berruezo, A.G.; Seraidy, S.; Parnas, A.; Tascón, I.; Ubarretxena-Belandia, I.; Azem, A.

Article / Structural basis for regulation of a CBASS-CRISPR-Cas defense island by a transmembrane anti-σ factor and its ECF σ partner

Science Advances

Bernal-Bernal, D.; Pantoja-Uceda, D.; López-Alonso, J.P.; López-Rojo, A.; López-Ruiz, J.A.; Galbis-Martínez, M.; Ochoa-Lizarralde, B.; Tascón, I.; Elías-Arnanz, M.; Ubarretxena-Belandia, I.; Padmanabhan, S.

2023

Article / Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane

Nature Communications

González-Magaña, A.; Tascón, I.; Altuna-Alvarez, J.; Queralt-Martín, M.; Colautti, J.; Velázquez, C.; Zabala, M.; Rojas-Palomino, J.; Cárdenas, M.; Alcaraz, A.; Whitney, J.C.; Ubarretxena-Belandia, I.; Albesa-Jové, D.

2022

Article / Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch

Nature Communications

Malik, R.; Johnson, R.E.; Prakash, L.; Prakash, S.; Ubarretxena-Belandia, I.; Aggarwal, A.K.

2021

Article / Conformational plasticity underlies membrane fusion induced by an HIV sequence juxtaposed to the lipid envelope

Scientific Reports

de la Arada, I.; Torralba, J.; Tascón, I.; Colom, A.; Ubarretxena-Belandia, I.; Arrondo, J.L.R.; Apellániz, B.; Nieva, J.L.

2020

Article / Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

Nature Communications

Gomez-Llorente, Y.; Jebara, F.; Patra, M.; Malik, R.; Nisemblat, S.; Chomsky-Hecht, O.; Parnas, A.; Azem, A.; Hirsch, J.A.; Ubarretxena-Belandia, I.

Article / Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

Nature Structural and Molecular Biology

Malik, R.; Kopylov, M.; Gomez-Llorente, Y.; Jain, R.; Johnson, R.E.; Prakash, L.; Prakash, S.; Ubarretxena-Belandia, I.; Aggarwal, A.K.

Article / Substrate interaction inhibits γ-secretase production of amyloid-β peptides

Chemical Communications

Zhao, J.; Xiao, Y.; Liu, X.; Kim, S.; Wu, X.; Barros, M.; Zhuang, R.; Hou, X.; Zhang, Y.; Robakis, N.K.; Li, Y.M.; Dordick, J.S.; Ubarretxena-Belandia, I.; Wang, C.

Article / Presenilin1 familial Alzheimer disease mutants inactivate EFNB1-and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-Aspartate receptor

Brain Communications

Al Rahim, M.; Yoon, Y.; Dimovasili, C.; Shao, Z.; Huang, Q.; Zhang, E.; Kezunovic, N.; Chen, L.; Schaffner, A.; Huntley, G.W.; Ubarretxena-Belandia, I.; Georgakopoulos, A.; Robakis, N.K.

Review / Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype

Frontiers in Molecular Neuroscience

Liu, X.; Zhao, J.; Zhang, Y.; Ubarretxena-Belandia, I.; Forth, S.; Lieberman, R.L.; Wang, C.

2019

Article / CD46 facilitates entry and dissemination of human cytomegalovirus

Nature Communications

Stein, K.R.; Gardner, T.J.; Hernandez, R.E.; Kraus, T.A.; Duty, J.A.; Ubarretxena-Belandia, I.; Moran, T.M.; Tortorella, D.

Article / Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

Nature Structural and Molecular Biology

Jain, R.; Rice, W.J.; Malik, R.; Johnson, R.E.; Prakash, L.; Prakash, S.; Ubarretxena-Belandia, I.; Aggarwal, A.K.

Biochemical and structural characterization of di-aspartyl intramembrane proteases

City University of New York

Celia Torres-Arancivia - Finished

Structural and biochemical characterization of Rhomboid intramembrane proteases

City University of New York

Jose Chavez - Finished

Design and validation of an open-source modular microplate photoirradiation system for high-through experiments in photobiology

Icahn School of Medicine at Mount Sinai

Suzanna Katz - Finished

Developing novel strategies to target LRRK2 in the fight against Parkinson

Icahn School of Medicine at Mount Sinai

Adam Schaffner - Finished

Iban Ubarretxena Belandia

Ikerbasque Research Professor, Director at Biofisika Institute (EHU-CSIC)

2025

2024

2023

2022

2021

2020

2019

2018

2006