Javier Muñoz Peralta

Ikerbasque Research Professor, IIS Biobizkaia

Ikerbasque Research Professor at Biobizkaia Health Research Institute.

Research line:

Mass Spectrometry-based Proteomics.

Young Investigator Award 2010 by the Human Proteome Organization (HUPO) and Ramon y Cajal Fellowship (2014-2018).

Previous research experience at Spanish National Cancer Research Center (CNIO) (Spain) and Utrecht University (The Netherlands).

PhD in Biochemistry (2007) from Center for Applied Medical Research (CIMA) (Spain).

Argitalpenak

2024

Article / Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver

Nature Communications

Plata-Gómez, A.B.; de Prado-Rivas, L.; Sanz, A.; Deleyto-Seldas, N.; García, F.; de la Calle Arregui, C.; Silva, C.; Caleiras, E.; Graña-Castro, O.; Piñeiro-Yáñez, E.; Krebs, J.; Leiva-Vega, L.; Muñoz, J.; Jain, A.; Sabio, G.; Efeyan, A.

2023

Article / An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

Nature Communications

Cuesta-Hernández, H.N.; Contreras, J.; Soriano-Maldonado, P.; Sánchez-Wandelmer, J.; Yeung, W.; Martín-Hurtado, A.; Muñoz, I.G.; Kannan, N.; Llimargas, M.; Muñoz, J.; Plaza-Menacho, I.

Article / Decoding protein methylation function with thermal stability analysis

Nature Communications

Sayago, C.; Sánchez-Wandelmer, J.; García, F.; Hurtado, B.; Lafarga, V.; Prieto, P.; Zarzuela, E.; Ximénez-Embún, P.; Ortega, S.; Megías, D.; Fernández-Capetillo, O.; Malumbres, M.; Munoz, J.

Article / Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology

Allergy: European Journal of Allergy and Clinical Immunology

Molina-Jiménez, F.; Ugalde-Triviño, L.; Arias-González, L.; Relaño-Rupérez, C.; Casabona, S.; Pérez-Fernández, M.T.; Martín-Domínguez, V.; Fernández-Pacheco, J.; Laserna-Mendieta, E.J.; Muñoz-Hernández, P.; Arias-Arias, Á.; Cano, A.; Muñoz, J.; Lucendo, A.J.; Santander, C.; Majano, P.

Letter / DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling

Cancer Communications

Mellid, S.; García, F.; Leandro-García, L.J.; Díaz-Talavera, A.; Martínez-Montes, Á.M.; Gil, E.; Calsina, B.; Monteagudo, M.; Letón, R.; Roldán-Romero, J.M.; Santos, M.; Lanillos, J.; Valdivia, C.; Martínez-Puente, N.; de Nicolás-Hernández, J.; Jiménez, S.; Pérez-Martínez, M.; Honrado, E.; Coloma, J.; Cerezo, A.; Santiveri, C.M.; Esteller, M.; Campos-Olivas, R.; Caleiras, E.; Montero-Conde, C.; Rodríguez-Antona, C.; Muñoz, J.; Robledo, M.; Cascón, A.

2022

Article / Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer

EMBO Molecular Medicine

Seidlitz, T.; Schmäche, T.; Garcίa, F.; Lee, J.H.; Qin, N.; Kochall, S.; Fohgrub, J.; Pauck, D.; Rothe, A.; Koo, B.K.; Weitz, J.; Remke, M.; Muñoz, J.; Stange, D.E.

Article / The lysosomal proteome of senescent cells contributes to the senescence secretome

Aging Cell

Rovira, M.; Sereda, R.; Pladevall-Morera, D.; Ramponi, V.; Marin, I.; Maus, M.; Madrigal-Matute, J.; Díaz, A.; García, F.; Muñoz, J.; Cuervo, A.M.; Serrano, M.

Article / Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis

Journal of Hepatology

Garrido, A.; Kim, E.; Teijeiro, A.; Sánchez Sánchez, P.; Gallo, R.; Nair, A.; Matamala Montoya, M.; Perna, C.; Vicent, G.P.; Muñoz, J.; Campos-Olivas, R.; Melms, J.C.; Izar, B.; Schwabe, R.F.; Djouder, N.

Article / A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

EMBO Molecular Medicine

Zhu, L.; Retana, D.; García-Gómez, P.; Álvaro-Espinosa, L.; Priego, N.; Masmudi-Martín, M.; Yebra, N.; Miarka, L.; Hernández-Encinas, E.; Blanco-Aparicio, C.; Martínez, S.; Sobrino, C.; Ajenjo, N.; Artiga, M.J.; Ortega-Paino, E.; Torres-Ruiz, R.; Rodríguez-Perales, S.; Soffietti, R.; Bertero, L.; Cassoni, P.; Weiss, T.; Muñoz, J.; Sepúlveda, J.M.; González-León, P.; Jiménez-Roldán, L.; Moreno, L.M.; Esteban, O.; Pérez-Núñez, Á.; Hernández-Laín, A.; Toldos, O.; Ruano, Y.; Alcázar, L.; Blasco, G.; Fernández-Alén, J.; Caleiras, E.; Lafarga, M.; Megías, D.; Graña-Castro, O.; Nör, C.; Taylor, M.D.; Young, L.S.; Varešlija, D.; Cosgrove, N.; Couch, F.J.; Cussó, L.; Desco, M.; Mouron, S.; Quintela-Fandino, M.; Weller, M.; Pastor, J.; Valiente, M.; de la Lama-Zaragoza, A.; Calero-Felix, L.; Fiaño-Valverde, C.; Delgado-López, P.D.; Montalvo-Afonso, A.; Pascual-Llorente, M.; Díaz-Piqueras, Á.; Nam-Cha, S.H.; Barrena López, C.; Plans Ahicart, G.; Martínez-Saez, E.; Ramón y Cajal, S.; Nicolás, P.

Article / Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

Science Advances

Kuo, S.H.; Tasset, I.; Cheng, M.M.; Diaz, A.; Pan, M.K.; Lieberman, O.J.; Hutten, S.J.; Alcalay, R.N.; Kim, S.; Ximénez-Embún, P.; Fan, L.; Kim, D.; Ko, H.S.; Yacoubian, T.; Kanter, E.; Liu, L.; Tang, G.; Muñoz, J.; Sardi, S.P.; Li, A.; Gan, L.; Cuervo, A.M.; Sulzer, D.

Review / Unraveling the complexity of the extracellular vesicle landscape with advanced proteomics

Expert Review of Proteomics

Morales-Sanfrutos, J.; Munoz, J.

2021

Article / A proteomic approach for systematic mapping of substrates of human deubiquitinating enzymes

International Journal of Molecular Sciences

Ramirez, J.; Prieto, G.; Olazabal-Herrero, A.; Borràs, E.; Fernandez-Vigo, E.; Alduntzin, U.; Osinalde, N.; Beaskoetxea, J.; Lectez, B.; Aloria, K.; Rodriguez, J.A.; Paradela, A.; Sabidó, E.; Muñoz, J.; Corrales, F.; Arizmendi, J.M.; Mayor, U.

Article / Reciprocal regulation of chaperone-mediated autophagy and the circadian clock

Nature Cell Biology

Juste, Y.R.; Kaushik, S.; Bourdenx, M.; Aflakpui, R.; Bandyopadhyay, S.; Garcia, F.; Diaz, A.; Lindenau, K.; Tu, V.; Krause, G.J.; Jafari, M.; Singh, R.; Muñoz, J.; Macian, F.; Cuervo, A.M.