Francisco Borrego

2019

CD300 receptor family in viral infections.

European Journal of Immunology

Joana Vitallé, Iñigo terrén, Ane Orrantia, Olatz Zenarruzabeitia, Francisco Borrego (2019)

CD300c co-stimulates IgE-mediated basophils activation and its expression is increased in cow´s milk allergy.

Journal of Allergy and Clinical Immunology

Olatz Zenarruzabeitia, Joana Vitallé, Iñigo Terrén, Ane Orrantia, Itziar Astigarraga, Leire Dopazo, Carlos González, Laura Santos-Díez, Carlos Tutau, Pedro M. Gamboa, Agurtzane Bilbao, Francisco Borrego. (2019)

2018

Long interleukin-22 binding protein isoform-1 is an intracellular activator of the unfolded protein response

Frontiers in Immunology

Paloma Gómez, Andoni Urtasun. Adrienne W. Paton, James C. Paton, Francisco Borrego, Devin Dersh, Argon Yair, Iraide Alloza, Koen Vandenbroeck. (2018)

Altered expression of CD300a inhibitory receptor on CD4+ T cells from HIV-1 infected patients: association with disease progression markers.

Frontiers in Immunology

Joana Vitallé, Iñigo Terrén, Leire Gamboa-Urquijo, Ane Orrantia, Laura Tarancón-Díez, Miguel Genebat, Ezequiel Ruiz-Mateos, Manuel Leal, Susana García-Obregón, Olatz Zenarruzabeitia, Francisco Borrego. (2018)

Implication of interleukin (IL)-12/15/18 and ruxolitinib in the phenotype, proliferation and polyfunctionality of human cytokine-preactivated NK cells.

Frontiers in Immunology

Iñigo Terrén, Idoia Mikelez, Irati Odriozola, Andrea Gredilla, Javier González, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Francisco Borrego. (2018)

Identification of a panel of potential serum protein markers in severe sepsis.

Journal of Microbiology, Immunology and Infection

Susana Garcia-Obregon, Mikel Azkargorta, Iratxe Seijas, Javier Pilar-Orive, Francisco Borrego, Félix Elortza, María D. Boyano, Itziar Astigarraga (2018)

2017

Buscando nuevas dianas para el tratamiento de alergias.

Inmunología

Francisco Borrego, Olatz Zenarruzabeitia, Joana Vitallé, Iñigo Terrén, Itziar Astigarraga, Agurtzane Bilbao, Leire Dopazo. (2017)

Natural Killer Cells to the Attack: Combination Therapy Against Neuroblastoma.

Clinical Cancer Research

Olatz Zenarruzabeitia, Joana Vitallé, Itziar Astigarraga, Francisco Borrego (2017)

OP9 feeder cells are superior for the generation of mature and functional NK cells from umbilical cord hematopoietic progenitors.

Frontiers in Immunology

Lara Herrera, Juan M. Salcedo, Silvia Santos, Miguel A. Vesga, Francisco Borrego, Cristina Eguizabal. (2017)

Monocytes phenotype and cytokine production in HIV-1 infected patients receiving a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B): relationship to CD300 molecules expression.

Frontiers in Immunology

Joana Vitallé, Olatz Zenarruzabeitia, Iñigo Terrén, Montserrat Plana, Alberto C. Guardo, Lorna Leal, José Peña, Felipe García, Francisco Borrego (2017)

2016

Células NK “memoria-like” pre-activadas con citoquinas: bases moleculares y uso potencial en inmunoterapia celular adoptiva.

Boletín de la Sociedad Española de Transfusión Sanguínea y Terapia Celular.

Olatz Zenarruzabeitia, Javier González, Andrea Gredilla, Joana Vitallé, Juan M. Salcedo, Lara Herrera, Cristina Eguizabal, Miguel A. Vesga, Francisco Borrego. (2016)

27 Congreso Anual de la SETS: Bilbao (España), 23-25 Junio 2016.

Blood Transfusion

Miguel A. Vesga, Miguel A. Pérez Vaquero, José L. Bueno, Itziar Ezpeleta, Salvador Oyonarte, Silvia Sauleda, Eduardo Muñiz-Díaz, Francisco Borrego. (2016)

The expression and function of human CD300 receptors on human blood circulating mononuclear cells are distinct in neonates and adults.

Scientific Reports

Olatz Zenarruzabeitia, Joana Vitallé, Susana García-Obregón, Itziar Astigarraga, Cristina Eguizabal, Silvia Santos, Venkateswara R. Simhadri, Francisco Borrego (2016)

NK cell-based cancer immunotherapy

Frontiers in Immunology

Francisco Borrego, Susana Larrucea, Rafael Solana, Raquel Tarazona (2016)

CD300c is uniquely expressed on CD56(bright) Natural Killer Cells and differs from CD300a upon ligand recognition.

Scientific Reports

Milena Dimitrova, Olatz Zenarruzabeitia, Francisco Borrego, and Venkateswara R. Simhadri. (2016)

FCRL5 expression distinguishes two distinct subsets of human circulating tissue-like memory B cells

Journal of Immunology

Huifang Li, Francisco Borrego, and Mate Tolnay (2016)

2015

The biology and disease relevance of CD300a, an inhibitory receptor for phosphatidylserine and phosphatidylethanolamine.

Journal of Immunology

Olatz Zenarruzabeitia, Joana Vitallé, Cristina Eguizabal, Venkateswara R. Simhadri, and Francisco Borrego. (2015)

A human anti-M2 antibody mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and cytokine secretion by resting and cytokine-induced “memory-like” natural killer (NK) cells.

PLOS One

Venkateswara R. Simhadri, Milena Dimitrova, John L. Mariano, Olatz Zenarruzabeitia, Weimin Zhong, Tatsuhiko Ozawa, Atsushi Muraguchi, Hiroyuki Kishi, and Francisco Borrego. (2015)

2014

Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1.

Frontiers in Oncology

Laura Amo, Estibaliz Tamayo-Orbegozo, Natalia Maruri, Cristina Eguizabal, Olatz Zenarruzabeitia, Marta Riñón, Arantza Arrieta, Silvia Santos, Jorge Monge, Miguel A. Vesga, Francisco Borrego, and Susana Larrucea. (2014)

Natural killer (NK) cells for immunotherapy: a special case for pluripotent stem cells-derived NK cells.

Frontiers in Immunology

Cristina Eguizabal, Olatz Zenarruzabeitia, Jorge Monge, Silvia Santos, Miguel A. Vesga, Natalia Maruri, Arantza Arrieta, Marta Riñón, Estibaliz Tamayo-Orbegozo, Laura Amo, Susana Larrucea, and Francisco Borrego. (2014)

Intact IL-12 signaling is necessary for the generation of human NK cells with enhanced effector function after restimulation.

Journal of Allergy and Clinical Immunology

Venkateswara R. Simhadri, John L. Mariano, Olatz Zenarruzabeitia, Christine M. Seroogy, Steven M. Holland, Hye S. Kuehn, Sergio D. Rosenzweig, and Francisco Borrego. (2014)

2013

Membrane-Type 6 Matrix Metalloproteinase Regulates the Activation-Induced Downmodulation of CD16 in Human Primary NK Cells

Journal of Immunology

Giovanna Peruzzi, Laurette Femnou, Aleksandra Gil-Krzewska, Francisco Borrego, Jennifer Weck, Konrad Krzewski and John E. Coligan (2013)

2018

Inmunología Tumoral e Inmunoterapia del Cáncer

Francisco Borrego

2015

Inmunoterapia del cáncer. Realidades y perspectivas.

Elsevier

Alena Gros, Marcela Maus, and Francisco Borrego

2015

Molecular bases of cytokine-induced "memory-like" natural killer (NK) cells

University of the Basque Country-University of Cantabria

2017

Invited Lecturer, Master in Molecular Biology and Biomedicine. “Cancer Immunotherapy”. Universidad del País Vasco/Euskal Herriko Unibersitatea-Universidad de Cantabria.

Director and Lecturer, Summer Course: “Immunology, Immunopathology and Immunotherapy”. XXXVI Edition of Summer Courses. Universidad del País Vasco/Euskal Herriko Unibersitatea.

2015

Workshop de Citometría de Flujo – Organizado por Inbiomed y BD Biosciences. Donostia-San Sebastián.

Invited Lecturer, Master in Molecular Biology and Biomedicine. “Cancer immunotherapy: increasing the therapeutic potential of natural killer cells against tumors”. Universidad del País Vasco/Euskal Herriko Unibersitatea-Universidad de Cantabria.

Invited Lecturer, Master in Biomedicine. “Cancer immunotherapy: increasing the therapeutic potential of natural killer cells against tumors”. Universidad de Cádiz.

2014

Invited Lecturer, Master in Molecular Biology and Biomedicine. “The CD300 molecules: an emerging family of regulators of the Immune System”. Universidad del País Vasco/Euskal Herriko Unibersitatea-Universidad de Cantabria.

2017

Councillor of the Spanish Association of Immunologist Council (vocal de la Junta Directiva de la Sociedad Española de Inmunología).

Member of the Ethics Committee for Clinical Research of the Basque Country.

Member of the Research Committee of Biocruces Health Research Institute.

2016

Councillor of the Spanish Association of Immunologist Council (vocal de la Junta Directiva de la Sociedad Española de Inmunología).

Member of the Ethics Committee for Clinical Research of the Basque Country.

2017

CD300c is a co-stimulatory receptor in IgE/Fc?RI-dependent human basophil activation

XL Annual Meeting of Spanish Association of Immunology - Congress

O. Zenarruzabeitia, J. Vitallé, L. Dopazo, A. Bilbao, C. Tutau, I. Astigarraga, and F. Borrego

Zaragoza (Spain) (Talk)

Obtención de progenitores hematopoyéticos CD34+ y células NK a partir de célula madre pluripotentes inducidas (iPSCs)

XXVIII Annual Meeting of the Spanish Association of Blood Transfusion and Cell Therapy- 2nd Spanish-Portuguese Congress of Transfusion Medicine and Cell Therapy - Congress

L. Herrera, J.M. Salcedo, F. Borrego, S. Santos, C. Rodríguez, J.M. Cárdenas, M.A. Vesga, and C. Eguizabal

Porto (Portugal) (Talk)

Las células soporte OP9 son superiores para la generación in vitro de células natural killer maduras y funcionales a partir de progenitores hematopoyéticos de cordón umbilical.

XV Congreso de la Asociación Española de Bancos de Tejidos. - Congress

L. Herrera, J.M. Salcedo, F. Borrego, C. Rodríguez, S. Santos, M.A. Vesga, and C. Eguizabal

Bilbao (Spain) (Talk)

Efecto del Ruxolitinib en la generación de células NK “memoria-like” inducidas por citoquinas (CIML).

XXIV reunión anual ASOVASNA. - Congress

I. Terrén, J. González, A. Gredilla, I. Odriozola, I. Mikelez, J. Vitallé, O. Zenarruzabeitia, and F. Borrego

Bilbao (Spain) (Poster)

Exploitation of immune cell iron oxide nanoparticle interaction for cancer immunotherapy.

International conference on nanomedicine and nanobiotechnology – ICONAN 2017 - Congress

I. Mikelez-Alonso, A. Ruiz de Angulo, F. Borrego, J.C. Mareque

Barcelona (Spain) (Poster)

Monocytes phenotype and cytokine production in HIV-1 infected patients receiving a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B): relationship to CD300 molecules expression.

IX Congreso Nacional de GESIDA 2017 - Congress

J. Vitallé, I. Terrén, M. Plana, A. Crespo, L. Leal, J. Peña, F. García, O. Zenarruzabeitia and F. Borrego.

Vigo (Spain) (Poster)

HIV-1 infection modulates CD300a inhibitory receptor expression on CD4+ T lymphocytes.

IX Congreso Nacional de GESIDA 2017. - Congress

J. Vitallé, I. Terrén, L. Tarancón, M. Genebat, E. Ruiz-Mateos, M. Leal, O. Zenarruzabeitia and F. Borrego

Vigo (Spain) (Poster)

CD300a inhibitory receptor expression is related to the exhaustion phenotype and functional capabilities of CD8+ T cells in HIV-1 infection.

IX Congreso Nacional de GESIDA 2017. - Congress

J. Vitallé, I. Terrén, L. Tarancón, M. Genebat, E. Ruiz-Mateos, M. Leal, O. Zenarruzabeitia and F. Borrego

Vigo (Spain) (Poster)

Member of the Scientific Committee

XL Annual Meeting of Spanish Association of Immunology. - Congress

Francisco Borrego

Zaragoza (Spain) (Organization and management)

Immunotherapy with umbilical cord derived NK cells

XV Congress of Spanish Association of Bank of Tissues - Congress

Francisco Borrego

Bilbao (Spain) (Invited talk)

2016

Células NK preactivadas con citoquinas: bases moleculares y uso potencial en inmunoterapia celular adoptiva.

XXVII Annual Meeting of the Spanish Association of Blood Transfusion and Cell Therapy. - Congress

F. Borrego, O. Zenarruzabeitia, J. Vitallé, A. Gredilla, J. González, J.M. Salcedo, L. Herrera, C. Eguizabal, and M.A. Vesga.

Bilbao (Spain) (Talk)

2015

Células NK “memoria-like” inducidas por citoquinas: bases moleculares y uso potencial en inmunoterapia celular adoptiva.

XXII reunión anual ASOVASNA (Asociación Vasco-Navarra de Hematología) - Congress

Irati Odriozola, Olatz Zenarruzabeitia, Joana Vitallé, Lara Herrera, Juan M. Salcedo, Cristina Eguizabal, Miguel A. Vesga, and Francisco Borrego.

Vitoria-Gasteiz (Poster)

Producción de CAR-NK de grado preclínico y determinación de la mejor fuente celular para la generación de CAR-NK.

XXII reunión anual ASOVASNA (Asociación Vasco-Navarra de Hematología) - Congress

Lara Herrera, Juan M. Salcedo, Olatz Zenarruzabeitia, Joana Vitallé, Irati Odriozola, Francisco Borrego, Miguel A. Vesga, and Cristina Eguizabal.

Vitoria-Gasteiz (Poster)

2014

Member of the Scientific Committee

Congreso Anual de la Sociedad Española de Inmunología. - Congress

Francisco Borrego

Badajoz (Organization and management)

Immunotherapy: Role of NK cells in the mechanism of action of therapeutic antibodies.

Congreso Anual de la Sociedad Española de Inmunología. - Congress

Francisco Borrego

Badajoz (Invited talk)

Francisco Borrego

Ikerbasque Research Professor, BioCruces