Francisco Borrego

Ikerbasque Research Professor, BioCruces

Ikerbasque Research Professor at BioCruces Health Research Institute.

Research line:

Immunology.

Previous research experience in United States: National Institute of Allergy and Infectious Diseases (NIAID-NIHD) and Food and Drug Administration (FDA).

Doctor in Medicine in 1994 from University of Cordoba.

2021

Article / Metabolic changes of Interleukin-12/15/18-stimulated human NK cells

Scientific Reports

Terrén, I.; Orrantia, A.; Mosteiro, A.; Vitallé, J.; Zenarruzabeitia, O.; Borrego, F. (2021)

Article / T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19

Frontiers in Immunology

Zenarruzabeitia, O.; Astarloa-Pando, G.; Terrén, I.; Orrantia, A.; Pérez-Garay, R.; Seijas-Betolaza, I.; Nieto-Arana, J.; Imaz-Ayo, N.; Pérez-Fernández, S.; Arana-Arri, E.; Borrego, F. (2021)

Letter / PIPE-cloned human IgE and IgG4 antibodies: New tools for investigating cow's milk allergy and tolerance

Allergy: European Journal of Allergy and Clinical Immunology

Pranger, C.L.; Fazekas-Singer, J.; Köhler, V.K.; Pali-Schöll, I.; Fiocchi, A.; Karagiannis, S.N.; Zenarruzabeitia, O.; Borrego, F.; Jensen-Jarolim, E. (2021)

Review / Human nk cells in autologous hematopoietic stem cell transplantation for cancer treatment

Cancers

Orrantia, A.; Terrén, I.; Astarloa-Pando, G.; Zenarruzabeitia, O.; Borrego, F. (2021)

Review / Nanoparticles and trained immunity: Glimpse into the future

Advanced Drug Delivery Reviews

Magadán, S.; Mikelez-Alonso, I.; Borrego, F.; González-Fernández, Á. (2021)

Review / Natural killer (NK) cell-based immunotherapies and the many faces of NK cell memory: A look into how nanoparticles enhance NK cell activity

Advanced Drug Delivery Reviews

Mikelez-Alonso, I.; Magadán, S.; González-Fernández, Á.; Borrego, F. (2021)

2020

Article / Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a

Scientific Reports

Vitallé, J.; Terrén, I.; Gamboa-Urquijo, L.; Orrantia, A.; Tarancón-Díez, L.; Genebat, M.; Leal, M.; Ruiz-Mateos, E.; Borrego, F.; Zenarruzabeitia, O. (2020)

Article / Modulating NK cell metabolism for cancer immunotherapy

Seminars in Hematology

Terrén, I.; Orrantia, A.; Vitallé, J.; Astarloa-Pando, G.; Zenarruzabeitia, O.; Borrego, F. (2020)

Article / A NKp80-Based Identification Strategy Reveals that CD56neg NK Cells Are Not Completely Dysfunctional in Health and Disease

iScience

Orrantia, A.; Terrén, I.; Izquierdo-Lafuente, A.; Alonso-Cabrera, J.A.; Sandá, V.; Vitallé, J.; Moreno, S.; Tasias, M.; Uranga, A.; González, C.; Mateos, J.J.; García-Ruiz, J.C.; Zenarruzabeitia, O.; Borrego, F. (2020)

Article / CD300a identifies a CD4+ memory T cell subset with a higher susceptibility to HIV-1 infection

AIDS (London, England)

Vitallé, J.; Tarancón-Díez, L.; Jiménez-Leon, M.R.; Terrén, I.; Orrantia, A.; Roca-Oporto, C.; López-Cortés, L.; Ruiz-Mateos, E.; Zenarruzabeitia, O.; Borrego, F. (2020)

Article / Identification and Functional Analysis of Human CD56neg NK Cells by Flow Cytometry

STAR Protocols

Orrantia, A.; Terrén, I.; Vitallé, J.; Astarloa-Pando, G.; Zenarruzabeitia, O.; Borrego, F. (2020)

Review / The expression and function of CD300 molecules in the main players of allergic responses: Mast cells, basophils and eosinophils

International Journal of Molecular Sciences

Vitallé, J.; Terrén, I.; Orrantia, A.; Bilbao, A.; Gamboa, P.M.; Borrego, F.; Zenarruzabeitia, O. (2020)

Review / NK cell-based immunotherapy in renal cell carcinoma

Cancers

Terrén, I.; Orrantia, A.; Mikelez-Alonso, I.; Vitallé, J.; Zenarruzabeitia, O.; Borrego, F. (2020)

2019

Article / CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

Cellular and Molecular Immunology

Vitallé, J.; Terrén, I.; Orrantia, A.; Pérez-Garay, R.; Vidal, F.; Iribarren, J.A.; Rodríguez, C.; Lirola, A.M.L.; Bernal, E.; Zenarruzabeitia, O.; Borrego, F. (2019)

Article / CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy

Journal of Allergy and Clinical Immunology

Zenarruzabeitia, O.; Vitallé, J.; Terrén, I.; Orrantia, A.; Astigarraga, I.; Dopazo, L.; Gonzalez, C.; Santos-Díez, L.; Tutau, C.; Gamboa, P.M.; Bilbao, A.; Borrego, F. (2019)

Letter / Increased expression levels of CD300c on basophils from allergic individuals

World Allergy Organization Journal

Vitallé, J.; Terrén, I.; Orrantia, A.; Segurola, A.; Seras, Y.; Gamboa, P.M.; Borrego, F.; Zenarruzabeitia, O. (2019)

Review / CD300 receptor family in viral infections

European Journal of Immunology

Vitallé, J.; Terrén, I.; Orrantia, A.; Zenarruzabeitia, O.; Borrego, F. (2019)

Short Survey / NK cell metabolism and tumor microenvironment

Frontiers in Immunology

Terrén, I.; Orrantia, A.; Vitallé, J.; Zenarruzabeitia, O.; Borrego, F. (2019)

2018

Article / Altered expression of CD300a inhibitory receptor on CD4+ T cells from HIV-1 infected patients: association with disease progression markers.

Frontiers in Immunology

Joana Vitallé, Iñigo Terrén, Leire Gamboa-Urquijo, Ane Orrantia, Laura Tarancón-Díez, Miguel Genebat, Ezequiel Ruiz-Mateos, Manuel Leal, Susana García-Obregón, Olatz Zenarruzabeitia, Francisco Borrego. (2018)

Article / Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response

Frontiers in immunology

Gómez-Fernández, P.; Urtasun, A.; Paton, A.W.; Paton, J.C.; Borrego, F.; Dersh, D.; Argon, Y.; Alloza, I.; Vandenbroeck, K. (2018)

Article / Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients

Journal of Microbiology, Immunology and Infection

Garcia-Obregon, S.; Azkargorta, M.; Seijas, I.; Pilar-Orive, J.; Borrego, F.; Elortza, F.; Boyano, M.D.; Astigarraga, I. (2018)

Article / Altered expression of CD300a inhibitory receptor on CD4+ T cells from human immunodeficiency virus-1-infected patients: Association with disease progression markers

Frontiers in Immunology

Vitallé, J.; Terrén, I.; Gamboa-Urquijo, L.; Orrantia, A.; Tarancón-Díez, L.; Genebat, M.; Ruiz-Mateos, E.; Leal, M.; García-Obregón, S.; Zenarruzabeitia, O.; Borrego, F. (2018)

Article / Implication of interleukin-12/15/18 and ruxolitinib in the phenotype, proliferation, and polyfunctionality of human cytokine-preactivated natural killer cells

Frontiers in Immunology

Terrén, I.; Mikelez, I.; Odriozola, I.; Gredilla, A.; González, J.; Orrantia, A.; Vitallé, J.; Zenarruzabeitia, O.; Borrego, F. (2018)

2017

Article / Monocytes phenotype and cytokine production in HIV-1 infected patients receiving a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B): relationship to CD300 molecules expression.

Frontiers in Immunology

Joana Vitallé, Olatz Zenarruzabeitia, Iñigo Terrén, Montserrat Plana, Alberto C. Guardo, Lorna Leal, José Peña, Felipe García, Francisco Borrego (2017)

Article / OP9 feeder cells are superior for the generation of mature and functional NK cells from umbilical cord hematopoietic progenitors.

Frontiers in Immunology

Lara Herrera, Juan M. Salcedo, Silvia Santos, Miguel A. Vesga, Francisco Borrego, Cristina Eguizabal. (2017)

Article / Buscando nuevas dianas para el tratamiento de alergias.

Inmunología

Francisco Borrego, Olatz Zenarruzabeitia, Joana Vitallé, Iñigo Terrén, Itziar Astigarraga, Agurtzane Bilbao, Leire Dopazo. (2017)

Article / Monocytes phenotype and cytokine production in human immunodeficiency virus-1 infected patients receiving a modified vaccinia ankara-based HIV-1 vaccine: Relationship to CD300 molecules expression

Frontiers in Immunology

Vitallé, J.; Zenarruzabeitia, O.; Terrén, I.; Plana, M.; Guardo, A.C.; Leal, L.; Peña, J.; García, F.; Borrego, F.; Mothe, B.; Cobarsi, P.; Rosàs, M.; Carmen Puertas, M.; Carrillo, J.; Blanco, J.; Martínez-Picado, J.; Clotet, B.; Brander, C.; Climent, N.; Alvarez, C.; Sánchez, S.; León, A.; Pich, J.; Arnaiz, J.A.; Torres, B.; Lucero, C.; Gatell, J.M.; Muñoz-Fernández, M.A.; de Quirós, J.C.L.B.; Jiménez, J.L.; Esteban, M.; Gómez, C.E.; Perdiguero, B.; García-Arriaza, J.; Cepeda, V.; Sánchez-Sorzano, C.O.; Gonzalez, N.; Alcamí, J.; Jiménez, L.; Benito, J.M.; Rallón, N. (2017)

Article / OP9 feeder cells are superior to M2-10B4 cells for the generation of mature and functional natural killer cells from umbilical cord hematopoietic progenitors

Frontiers in Immunology

Herrera, L.; Salcedo, J.M.; Santos, S.; Vesga, M.Á.; Borrego, F.; Eguizabal, C. (2017)

Article / Natural killer cells to the attack: Combination therapy against neuroblastoma

Clinical Cancer Research

Zenarruzabeitia, O.; Vitallé, J.; Astigarraga, I.; Borrego, F. (2017)

2016

Article / FCRL5 expression distinguishes two distinct subsets of human circulating tissue-like memory B cells

Journal of Immunology

Huifang Li, Francisco Borrego, and Mate Tolnay (2016)

Article / NK cell-based cancer immunotherapy

Frontiers in Immunology

Francisco Borrego, Susana Larrucea, Rafael Solana, Raquel Tarazona (2016)

Article / The expression and function of human CD300 receptors on human blood circulating mononuclear cells are distinct in neonates and adults.

Scientific Reports

Olatz Zenarruzabeitia, Joana Vitallé, Susana García-Obregón, Itziar Astigarraga, Cristina Eguizabal, Silvia Santos, Venkateswara R. Simhadri, Francisco Borrego (2016)

Article / 27 Congreso Anual de la SETS: Bilbao (España), 23-25 Junio 2016.

Blood Transfusion

Miguel A. Vesga, Miguel A. Pérez Vaquero, José L. Bueno, Itziar Ezpeleta, Salvador Oyonarte, Silvia Sauleda, Eduardo Muñiz-Díaz, Francisco Borrego. (2016)

Article / Células NK “memoria-like” pre-activadas con citoquinas: bases moleculares y uso potencial en inmunoterapia celular adoptiva.

Boletín de la Sociedad Española de Transfusión Sanguínea y Terapia Celular.

Olatz Zenarruzabeitia, Javier González, Andrea Gredilla, Joana Vitallé, Juan M. Salcedo, Lara Herrera, Cristina Eguizabal, Miguel A. Vesga, Francisco Borrego. (2016)

Article / The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults

Scientific Reports

Zenarruzabeitia, O.; Vitallé, J.; García-Obregón, S.; Astigarraga, I.; Eguizabal, C.; Santos, S.; Simhadri, V.R.; Borrego, F. (2016)

Article / Fc receptor-like 5 expression distinguishes two distinct subsets of human circulating tissue-like memory b cells

Journal of Immunology

Li, H.; Borrego, F.; Nagata, S.; Tolnay, M. (2016)

Article / CD300c is uniquely expressed on CD56bright Natural Killer Cells and differs from CD300a upon ligand recognition

Scientific Reports

Dimitrova, M.; Zenarruzabeitia, O.; Borrego, F.; Simhadri, V.R. (2016)

Editorial / Editorial: NK cell-based cancer immunotherapy

Frontiers in Immunology

Borrego, F.; Larrucea, S.; Solana, R.; Tarazona, R. (2016)

2015

Article / A human anti-M2 antibody mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and cytokine secretion by resting and cytokine-preactivated natural killer (NK) cells

PLoS ONE

Simhadri, V.R.; Dimitrova, M.; Mariano, J.L.; Zenarruzabeitia, O.; Zhong, W.; Ozawa, T.; Muraguchi, A.; Kishi, H.; Eichelberger, M.C.; Borrego, F. (2015)

Review / The biology and disease relevance of CD300a, an inhibitory receptor for phosphatidylserine and phosphatidylethanolamine

Journal of Immunology

Zenarruzabeitia, O.; Vitallé, J.; Eguizabal, C.; Simhadri, V.R.; Borrego, F. (2015)

2014

Article / Intact IL-12 signaling is necessary for the generation of human natural killer cells with enhanced effector function after restimulation

Journal of Allergy and Clinical Immunology

Simhadri, V.R.; Mariano, J.L.; Zenarruzabeitia, O.; Seroogy, C.M.; Holland, S.M.; Kuehn, H.S.; Rosenzweig, S.D.; Borrego, F. (2014)

Short Survey / Natural killer cells for cancer immunotherapy: Pluripotent stem cells-derived NK cells as an immunotherapeutic perspective

Frontiers in Immunology

Eguizabal, C.; Zenarruzabeitia, O.; Monge, J.; Santos, S.; Vesga, M.A.; Maruri, N.; Arrieta, A.; Riñón, M.; Tamayo-Orbegozo, E.; Amo, L.; Larrucea, S.; Borrego, F. (2014)

Short Survey / Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1

Frontiers in Oncology

Amo, L.; Tamayo-Orbegozo, E.; Maruri, N.; Eguizabal, C.; Zenarruzabeitia, O.; Riñón, M.; Arrieta, A.; Santos, S.; Monge, J.; Vesga, M.A.; Borrego, F.; Larrucea, S. (2014)

2013

Article / Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells

Journal of Immunology

Peruzzi, G.; Femnou, L.; Gil-Krzewska, A.; Borrego, F.; Weck, J.; Krzewski, K.; Coligan, J.E. (2013)

2020

Chapter / Inmunoterapias y biomarcadores

J. Kalil, P. Giavina-Bianchi, F. Borrego

Chapter / Capítulo 8: Células linfoides innatas: papel en la inmunidad y en las enfermedades inmunomediadas.

F. Borrego, I. terrén

2018

Book / Inmunología Tumoral e Inmunoterapia del Cáncer

Francisco Borrego

Chapter / Capítulo 12: Regulación de la citotoxicidad de las células NK.

Borrego, Francisco

2015

Chapter / Inmunoterapia del cáncer. Realidades y perspectivas.

Alena Gros, Marcela Maus, and Francisco Borrego

Reconstitución de la población de células NK tras el trasplante de precursores hematopoyéticos autólogo. Identificación de biomarcadores que se asocien con el pronóstico de la enfermedad