Ignacio Torres Alemán

Ikerbasque Research Professor, Scientific Director at Achucarro

Scientific Director at Achucarro - Basque center for Neuroscience.

Research line:

Neurobiology of insulin peptides.

Fundación Mediterranea Fellowship, CajaMadrid Fellowship, Spanish Ministry of Education Fellowship, European Science Foundation Scholar, Fulbright Scholar, Mellon Foundation Fellowship, Pfizer Award for Biomedical Research, Madri+d Patent Award.

Previous research experience at Hospital Clinico de Madrid (Spain), Tulane University (USA), Yale University (USA) and Instituto Cajal (Spain).

PhD in Biology (1982) from Complutense University of Madrid.

Publications
Managerial activities

2024

Article / A role for astrocytic insulin-like growth factor I receptors in the response to ischemic insult.

Journal Cerebral Blood Flow and Metabolism

Suda K, Pignatelli J, Genis L, Fernandez AM, de Sevilla EF, de la Cruz IF, Pozo-Rodrigalvarez A, de Ceballos ML, Díaz-Pacheco S, Herrero-Labrador R, Aleman IT

Editorial / Untangling IGF-I signaling in the aging brain

Aging

Jonathan A. Zegarra‑Valdivia · Angel Nuñez · Ignacio Torres Aleman

2023

Article / Insulin regulates neurovascular coupling through astrocytes

Proceedings National Academy of Sciences (USA)

Ana M. Fernandeza,b , Laura Martinez-Rachadella,b, Marta Navarretea , Julia Pose-Utrillab,c, Jose Carlos Davilab,d , Jaime Pignatellia,b , Sonia Diaz-Pachecoa, Santiago Guerra-Canteraa,b , Emilia Viedma-Morenoa,b, Rocio Palenzuelae, Samuel Ruiz de Martin Estebane , Ricardo Mostanyf , Cristina Garcia-Caceresg, Matthias Tsch€opg, Teresa Iglesiasb,c , Maria L. de Ceballosa , Antonia Gutierrezb,d , and Ignacio Torres Alemanb,h,i,1

Article / Insulin‑like growth factor I sensitization rejuvenates sleep patterns in old mice

GeroScience

Jonathan A. Zegarra‑Valdivia · Jansen Fernandes · Maria Estrella Fernandez de Sevilla · Angel Trueba‑Saiz · Jaime Pignatelli · Kentaro Suda · Laura Martinez‑Rachadell · Ana Maria Fernandez · Julio Esparza · Miguel Vega · Angel Nuñez · Ignacio Torres Aleman

Article / Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypo-Thalamic Orexin Neurons

International Journal of Molecular Sciences

Jaime Pignatelli 1,2,* , M. Estrella Fernandez de Sevilla 1,2,3 , Jacob Sperber 1, Daniel Horrillo 4, Gema Medina-Gomez 4 and Ignacio Torres Aleman

Article / Astrocytic IGF-IRs Induce Adenosine-Mediated Inhibitory Downregulation and Improve Sensory Discrimination

Journal of Neuroscience

José Antonio Noriega-Prieto,1,7p Laura Eva Maglio,1,2p Jonathan A. Zegarra-Valdivia,3,4,5 Jaime Pignatelli,3,4 Ana M. Fernandez,3,4 Laura Martinez-Rachadell,3,4 Jansen Fernandes,3,6 Ángel Núñez,1 Alfonso Araque,7 Ignacio Torres-Alemán,3,4 and David Fernández de Sevilla1

Article / Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

F1000Research

Jonathan Zegarra-Valdivia1-4, Ana M. Fernandez2,3, Laura Martinez-Rachadell2,3, Raquel Herrero-Labrador2,3, Jansen Fernandes2,5, Ignacio Torres Aleman

Article / Electroactive materials surface charge impacts neuron viability and maturation in 2D cultures

ACS Applied Materials & Interfaces

Marques-Almeida T, Ribeiro C, Irastorza I, Miranda-Azpiazu P, Torres-Alemán I, Silvan U, and Lanceros-Méndez S

Article / Electroactive Materials Surface Charge Impacts Neuron Viability and Maturation in 2D Cultures

ACS Applied Materials and Interfaces

Marques-Almeida, T.; Ribeiro, C.; Irastorza, I.; Miranda-Azpiazu, P.; Torres-Alemán, I.; Silvan, U.; Lanceros-Méndez, S.

Article / Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior

Life Science Alliance

Herrero-Labrador, R.; Fernández-Irigoyen, J.; Vecino, R.; González-Arias, C.; Ausín, K.; Crespo, I.; Fernández Acosta, F.J.; Nieto-Estévez, V.; Román, M.J.; Perea, G.; Torres-Alemán, I.; Santamaría, E.; Vicario, C.

Review / Cognitive Deficits in Aging Related to Changes in Basal Forebrain Neuronal Activity

Cells

Chaves-Coira, I.; García-Magro, N.; Zegarra-Valdivia, J.; Torres-Alemán, I.; Núñez, Á.

Review / The neurobiology of insulin-like growth factor I: From neuroprotection to modulation of brain states

Molecular Psychiatry

Nuñez, A.; Zegarra-Valdivia, J.; Fernandez de Sevilla, D.; Pignatelli, J.; Torres Aleman, I.

Review / The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer’s Disease

International Journal of Molecular Sciences

Zegarra-Valdivia, J.A.; Pignatelli, J.; Nuñez, A.; Torres Aleman, I.

2022

Article / Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons

Molecular Psychiatry

Fernández de Sevilla, M.E.; Pignatelli, J.; Zegarra-Valdivia, J.A.; Mendez, P.; Nuñez, A.; Torres Alemán, I.

Article / Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of Mice Was Reduced in Aging

Cells

García-Magro, N.; Zegarra-Valdivia, J.A.; Troyas-Martinez, S.; Torres-Aleman, I.; Nuñez, A.

Article / Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimers-like pathology

F1000Research

Torres Aleman, I.; Zegarra-Valdivia, J.; Fernandez, A.M.; Martinez-Rachadell, L.; Herrero-Labrador, R.; Fernandes, J.

Article / Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

F1000Research

Zegarra-Valdivia, J.; Fernandez, A.M.; Martinez-Rachadell, L.; Herrero-Labrador, R.; Fernandes, J.; Torres Aleman, I.